Clayton E. Mathews

Chapter 24 Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production.

Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice.

Innate inflammation drives NK cell activation to impair Treg activity.

Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice.

New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.

Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.

ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential.

Rodent models for the study of type 2 diabetes in children (juvenile diabesity).

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.

Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.

Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction.

Utility of murine models for the study of spontaneous autoimmune type 1 diabetes.

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.

Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.

Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production.

Autoreactive T-cell responses: new technology in pursuit of an old nemesis.

MerTK is required for apoptotic cell-induced T cell tolerance.

mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.

Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes.

Role of increased ROS dissipation in prevention of T1D.

MerTK regulates thymic selection of autoreactive T cells.

Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter.

Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.

Use of nonobese diabetic mice to understand human type 1 diabetes.

NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.

mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.

Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.

Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.

Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.

Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.

Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.

Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.

Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.

Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.

The use of leptin as treatment for type 1 diabetes mellitus: counterpoint.

Role of genetics in resistance to type 1 diabetes.

Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.

Inherited β-cell dysfunction in lean individuals with type 2 diabetes.

Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines.

Oxidative stress and beta cell dysfunction.

Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.

Do β-cells generate peroxynitrite in response to cytokine treatment?

Use of chemical probes to detect mitochondrial ROS by flow cytometry and spectrofluorometry.

In search of a surrogate: engineering human beta cell lines for therapy.

Metabolic abnormalities in the pathogenesis of type 1 diabetes.

Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.

Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.

How the location of superoxide generation influences the β-cell response to nitric oxide.

Reply to Gurgul-Convey and Lenzen: Cytokines, nitric oxide, and β-cells.

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.

Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.

Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.

Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells.

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.

Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes.

Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes.

Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy.

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.

Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.

T cells display mitochondria hyperpolarization in human type 1 diabetes.

Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment.

The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice.

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes.

Mitochondrial Reactive Oxygen Species and Type 1 Diabetes.

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.

The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.

Abnormal islet sphingolipid metabolism in type 1 diabetes.

Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.

Correction to: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes.

Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells.

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.

Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.

Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation via Cross-Presentation in Type 1 Diabetes.

Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.

NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers.

Lipid mediators and biomarkers associated with type 1 diabetes development.

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.

Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.

Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3.

Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.

Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease.

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.