Stuart C. Sealfon

Strategies for mapping the binding site of the serotonin 5-HT2A receptor.

Monitoring G-protein-coupled receptor signaling with DNA microarrays and real-time polymerase chain reaction.

Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays.

Coupling of GnRH concentration and the GnRH receptor-activated gene program.

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

Validated genomic approach to study differentially expressed genes in complex tissues.

Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.

Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines.

Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor.

Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex.

Structure of the GnRH receptor-stimulated signaling network: insights from genomics.

Focused microarray analysis.

Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress.

Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression.

Genomics view of gonadotrope signaling circuits.

Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.

Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain.

CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis.

Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia.

Teaching resources. G-protein-coupled receptors.

Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone.

Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization.

Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo.

The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells.

Influenza virus evades innate and adaptive immunity via the NS1 protein.

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone.

p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition.

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.

Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats.

Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription.

BioPP: a tool for web-publication of biological networks.

Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells.

Noise propagation and scaling in regulation of gonadotrope biosynthesis.

Time and length scales of autocrine signals in three dimensions.

Identification of a serotonin/glutamate receptor complex implicated in psychosis.

Getting started in biological pathway construction and analysis.

Cell-to-cell communication: time and length scales of ligand internalization in cultures of suspended cells.

Receptor pair for schizophrenia.

A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood.

Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus.

Antiviral-activated dendritic cells: a paracrine-induced response state.

SOME STEP-DOWN PROCEDURES CONTROLLING THE FALSE DISCOVERY RATE UNDER DEPENDENCE.

Psychedelics and schizophrenia.

Agonist-trafficking and hallucinogens.

Microtranscriptome regulation by gonadotropin-releasing hormone.

Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication.

Group II metabotropic glutamate receptors and schizophrenia.

Multiple testing and its applications to microarrays.

Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.

Antiviral response dictated by choreographed cascade of transcription factors.

Coregulation mapping based on individual phenotypic variation in response to virus infection.

Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows.

Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase.

Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics.

Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study.

Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation.

Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase.

Misty Mountain clustering: application to fast unsupervised flow cytometry gating.

RNA and DNA microarrays.

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists.

Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells.

Differential gene expression in patients with amyotrophic lateral sclerosis.

Characterization of a MAPK scaffolding protein logic gate in gonadotropes.

Improved compensation in flow cytometry by multivariable optimization.

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.

Authors response to correspondence about an improved compensation method.

Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes.

Multi-scale stochastic simulation of diffusion-coupled agents and its application to cell culture simulation.