Department of Pediatrics
I did my undergraduate studies at the Nankai University in computer science, graduating in 2001. I received a M.S. in computer science from Wayne State University mentored by Dr. Sorin Draghici in 2004. I received a Ph.D. in genomics and computational biology from the University of Pennsylvania in 2010. The title of my dissertation was “The quantitative prediction of signal pathway activity through genome-wide gene expression data“, and Lewis A. Chodosh was my advisor. In 2010, I joined the Neurological Research Institute at the Baylor College of Medicine.
My research interests include topics in genomics, transcription regulation, disease genes prioritization, and machine learning. I often examine problems in these areas using methods and models from computer science, statistics, and related disciplines. Recently, I have been working on using Graphical Models to integrate multiple data types in the interest of advancing our understanding of neurological diseases.
Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
Genes & development Mar, 2013 | Pubmed ID: 23431031
Digital sorting of complex tissues for cell type-specific gene expression profiles.
BMC bioinformatics Mar, 2013 | Pubmed ID: 23497278
Expression and Functional Pathway Analysis of Nuclear Receptor NR2F2 in Ovarian Cancer.
The Journal of clinical endocrinology and metabolism May, 2013 | Pubmed ID: 23690307
NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation.
Human molecular genetics Feb, 2014 | Pubmed ID: 24105472
Combinatorial therapy discovery using mixed integer linear programming.
Bioinformatics (Oxford, England) May, 2014 | Pubmed ID: 24463180
On the reproducibility of TCGA ovarian cancer microRNA profiles.
PloS one , 2014 | Pubmed ID: 24489963
Molecular pathway identification using biological network-regularized logistic models.
BMC genomics , 2013 | Pubmed ID: 24564637
Serine catabolism regulates mitochondrial redox control during hypoxia.
Cancer discovery Dec, 2014 | Pubmed ID: 25186948
A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.
Cell Sep, 2014 | Pubmed ID: 25259927
FOXG1 expression shows correlation with neuronal differentiation in cerebellar development, aggressive phenotype in medulloblastomas, and survival in a xenograft model of medulloblastoma.
Human pathology Dec, 2015 | Pubmed ID: 26433703
TCGA2STAT: simple TCGA data access for integrated statistical analysis in R.
Bioinformatics (Oxford, England) 03, 2016 | Pubmed ID: 26568634
Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders.
Molecular brain Nov, 2015 | Pubmed ID: 26572867
Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides.
Nature Dec, 2015 | Pubmed ID: 26605526
Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 06, 2016 | Pubmed ID: 27079753
Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.
Human molecular genetics 08, 2016 | Pubmed ID: 27365498
Graphical Models via Univariate Exponential Family Distributions.
Journal of machine learning research : JMLR Dec, 2015 | Pubmed ID: 27570498
XMRF: an R package to fit Markov Networks to high-throughput genetics data.
BMC systems biology 08, 2016 | Pubmed ID: 27586041
Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing.
PloS one , 2016 | Pubmed ID: 27918591
Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models.
Human molecular genetics 12, 2016 | Pubmed ID: 28007900
Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine.
Cellular and molecular gastroenterology and hepatology Jan, 2017 | Pubmed ID: 28174757
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Nature genetics Apr, 2017 | Pubmed ID: 28288114
Comprehensive evaluation of RNA-seq quantification methods for linearity.
BMC bioinformatics Mar, 2017 | Pubmed ID: 28361706
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.
American journal of human genetics Jun, 2017 | Pubmed ID: 28502612
CRISPRcloud: a secure cloud-based pipeline for CRISPR pooled screen deconvolution.
Bioinformatics (Oxford, England) Sep, 2017 | Pubmed ID: 28541456
Disease-related gene module detection based on a multi-label propagation clustering algorithm.
PloS one , 2017 | Pubmed ID: 28542379
A Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas.
The Journal of clinical endocrinology and metabolism 09, 2017 | Pubmed ID: 28637297
Data Analysis Pipeline for RNA-seq Experiments: From Differential Expression to Cryptic Splicing.
Current protocols in bioinformatics 09, 2017 | Pubmed ID: 28902396
The International Conference on Intelligent Biology and Medicine (ICIBM) 2016: from big data to big analytical tools.
BMC bioinformatics Oct, 2017 | Pubmed ID: 28984189
The International Conference on Intelligent Biology and Medicine (ICIBM) 2016: summary and innovation in genomics.
BMC genomics Oct, 2017 | Pubmed ID: 28984207
An ultra-fast and scalable quantification pipeline for transposable elements from next generation sequencing data.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing , 2018 | Pubmed ID: 29218879
POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2018 | Pubmed ID: 29305536
Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2018 | Pubmed ID: 29382756
Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.
American journal of human genetics 02, 2018 | Pubmed ID: 29395075
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Neuron 03, 2018 | Pubmed ID: 29526553
Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity.
eLife 03, 2018 | Pubmed ID: 29570050
Detecting hidden batch factors through data-adaptive adjustment for biological effects.
Bioinformatics (Oxford, England) 04, 2018 | Pubmed ID: 29617963
Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
Nature neuroscience 06, 2018 | Pubmed ID: 29802390
Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in .
eLife 05, 2018 | Pubmed ID: 29809154
Tau Activates Transposable Elements in Alzheimer's Disease.
Cell reports Jun, 2018 | Pubmed ID: 29874575
High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration.
Cell systems 07, 2018 | Pubmed ID: 29936182
Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations.
Nature communications 08, 2018 | Pubmed ID: 30104565
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.
The Journal of experimental medicine Sep, 2018 | Pubmed ID: 30108137
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2018 | Pubmed ID: 30249792
RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins.
Cell reports Oct, 2018 | Pubmed ID: 30332651
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease.
Neuron 12, 2018 | Pubmed ID: 30415998
Metabolomics of mammalian brain reveals regional differences.
BMC systems biology 12, 2018 | Pubmed ID: 30577853
An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function.
Molecular psychiatry Jan, 2019 | Pubmed ID: 30610205
Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection.
Nature neuroscience 02, 2019 | Pubmed ID: 30664766
A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability.
Molecular psychiatry Jan, 2019 | Pubmed ID: 30696942
Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives.
Genome research 06, 2019 | Pubmed ID: 31015259
Author Correction: Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection.
Nature neuroscience Jun, 2019 | Pubmed ID: 31222187
1Program in Developmental Biology, Baylor College of Medicine,
2Medical Scientist Training Program, Baylor College of Medicine,
3Department of Pediatrics, Baylor College of Medicine,
4Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital,
5Department of Molecular and Human Genetics, Baylor College of Medicine,
6Department of Neuroscience, Baylor College of Medicine,
7Howard Hughes Medical Institute, Baylor College of Medicine