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Department of Molecular and Cellular Physiology
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ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.
The Journal of experimental medicine Mar, 2010 | Pubmed ID: 20156974
Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.
Neurobiology of disease Jan, 2013 | Pubmed ID: 22940630
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.
Nature immunology Feb, 2013 | Pubmed ID: 23377202
Identification and manipulation of biliary metaplasia in pancreatic tumors.
Gastroenterology Jan, 2014 | Pubmed ID: 23999170
ADAM10 regulates Notch function in intestinal stem cells of mice.
Gastroenterology Oct, 2014 | Pubmed ID: 25038433
Somatostatin receptor subtype 2 as pancreatic tumorigenesis suppressor: identification of a new targetable signaling node.
Gastroenterology Jun, 2015 | Pubmed ID: 25921374
Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2015 | Pubmed ID: 26338334
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Nature medicine Nov, 2015 | Pubmed ID: 26501191
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2016 | Pubmed ID: 26929329
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.
Cell reports Mar, 2016 | Pubmed ID: 26947075
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.
Cell Aug, 2016 | Pubmed ID: 27477511
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Genes & development 12, 2016 | Pubmed ID: 28087712
Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis.
Cellular and molecular gastroenterology and hepatology Jan, 2017 | Pubmed ID: 28090569
Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice.
eLife 10, 2017 | Pubmed ID: 28980940
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.
Nature communications 11, 2017 | Pubmed ID: 29170413
HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.
eLife 08, 2018 | Pubmed ID: 30074477
STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis.
Genes & development 09, 2018 | Pubmed ID: 30135074
Epithelial-Stromal Interactions in Pancreatic Cancer.
Annual review of physiology Feb, 2019 | Pubmed ID: 30418798
Spatial and phenotypic immune profiling of metastatic colon cancer.
JCI insight 11, 2018 | Pubmed ID: 30429368
The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.
Cellular and molecular gastroenterology and hepatology , 2019 | Pubmed ID: 30510993
Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis.
Gastroenterology 05, 2019 | Pubmed ID: 30716326
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Cell metabolism Jun, 2019 | Pubmed ID: 30827862
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.
Genes & development Jun, 2019 | Pubmed ID: 31048544
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.
Cellular and molecular gastroenterology and hepatology May, 2019 | Pubmed ID: 31125624
Hiding in plain sight.
Science (New York, N.Y.) 06, 2019 | Pubmed ID: 31221844
University of Michigan
Jenny Lazarus1,
Yagiz Akiska1,
Mirna Perusina Lanfranca1,
Lawrence Delrosario1,
Lei Sun1,
Daniel Long2,
Jiaqi Shi3,
Howard Crawford2,
Marina P. Di Magliano1,
Weiping Zou1,
Timothy Frankel1
1Department of Surgery, University of Michigan,
2Department of Molecular and Cellular Physiology, University of Michigan,
3Department of Pathology, University of Michigan
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