Howard Crawford

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

ADAM10 regulates Notch function in intestinal stem cells of mice.

Somatostatin receptor subtype 2 as pancreatic tumorigenesis suppressor: identification of a new targetable signaling node.

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17.

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.

Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis.

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice.

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis.

Epithelial-Stromal Interactions in Pancreatic Cancer.

Spatial and phenotypic immune profiling of metastatic colon cancer.

The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.

Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis.

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.

Hiding in plain sight.