Michael L. Dustin

Costimulation and endogenous MHC ligands contribute to T cell recognition.

Membrane domains and the immunological synapse: keeping T cells resting and ready.

T cell receptor signaling precedes immunological synapse formation.

WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation.

Polar redistribution of the sialoglycoprotein CD43: implications for T cell function.

Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms.

The immunological synapse.

Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation.

Shmoos, rafts, and uropods- the many facets of cell polarity.

Cutting edge: quantitative imaging of raft accumulation in the immunological synapse.

T-cell activation: a multidimensional signaling network.

The immunological synapse: integrins take the stage.

Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.

The synapse assembly model.

Neural and immunological synaptic relations.

Regulation of T cell migration through formation of immunological synapses: the stop signal hypothesis.

Coordination of T cell activation and migration through formation of the immunological synapse.

In vivo imaging approaches in animal models of rheumatoid arthritis.

Supported planar bilayers in studies on immune cell adhesion and communication.

The immunological synapse balances T cell receptor signaling and degradation.

In silico models for cellular and molecular immunology: successes, promises and challenges.

Cytotoxic T lymphocytes form an antigen-independent ring junction.

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.

Membranes as messengers in T cell adhesion signaling.

LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation.

What is the importance of the immunological synapse?

T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation.

Stop and go traffic to tune T cell responses.

A polarizing situation.

Visualizing dendritic cell networks in vivo.

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids.

Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.

ICAM-1 co-stimulates target cells to facilitate antigen presentation.

ATP mediates rapid microglial response to local brain injury in vivo.

A model for CD2/CD58-mediated adhesion strengthening.

Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo.

A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling.

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.

A dynamic view of the immunological synapse.

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

Altered TCR signaling from geometrically repatterned immunological synapses.

CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

T cells like a firm molecular handshake.

T cell-dendritic cell immunological synapses.

Dynamic imaging of the immune system: progress, pitfalls and promise.

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

Immunology. When F-actin becomes too much of a good thing.

Lateral membrane waves constitute a universal dynamic pattern of motile cells.

Innate response to focal necrotic injury inside the blood-brain barrier.

Impact of the immunological synapse on T cell signaling.

Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules.

Control of antigen presentation with a photoreleasable agonist peptide.

Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion.

Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells.

In vivo imaging of germinal centres reveals a dynamic open structure.

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

Requirements for T lymphocyte migration in explanted lymph nodes.

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.

Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes.

Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.

Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses.

Dynamics of host defense: the view at the front lines.

Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells.

Tug of war at the exit door.

T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation.

Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.

T-cell activation through immunological synapses and kinapses.

Synaptic asymmetry to go.

Measuring diffusion and binding kinetics by contact area FRAP.

A coupled diffusion-kinetics model for analysis of contact-area FRAP experiment.

Supported planar bilayers for study of the immunological synapse.

Micropatterning of costimulatory ligands enhances CD4+ T cell function.

Th1 and Th2 cells form morphologically distinct immunological synapses.

Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion.

Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells.

Modulation of T cell activation by stomatin-like protein 2.

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.

Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.

T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.

Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse.

Lrp4 is a receptor for Agrin and forms a complex with MuSK.

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis.

Visualization of cell-cell interaction contacts-synapses and kinapses.

Renal dendritic cells: an update.

Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

T cell antigen receptor signaling and immunological synapse stability require myosin IIA.

Visualizing immune system complexity.

The cellular context of T cell signaling.

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells.

Supported bilayers at the vanguard of immune cell activation studies.

Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse.

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.

The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.

Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse.

Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse.

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites.

Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.

Insights into function of the immunological synapse from studies with supported planar bilayers.

Functional anatomy of T cell activation and synapse formation.

Modular design of immunological synapses and kinapses.

Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.

Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.

Affinity measured by microcluster.

Cytotoxic immunological synapses.

High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells.

Development and migration of plasma cells in the mouse lymph node.

Understanding the structure and function of the immunological synapse.

HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse.

Signaling microdomains in T cells.

CTLs respond with activation and granule secretion when serving as targets for T-cell recognition.

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Dynamic imaging of the effector immune response to listeria infection in vivo.

Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection.

Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254.

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274.

Nanoengineering of Immune Cell Function.

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center.

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies.

The critical role of agrin in the hematopoietic stem cell niche.

PKC-θ function at the immunological synapse: prospects for therapeutic targeting.

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain.

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses.

HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA).

New insights into the T cell synapse from single molecule techniques.

PKC-θ: hitting the bull's eye.

Integrin inside-out signaling and the immunological synapse.

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.

Immunology. Antigen feast or famine.

Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses.

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.

Self-reactive human CD4 T cell clones form unusual immunological synapses.

Mechanosensing in T lymphocyte activation.

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.

Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility.

TCR signaling: the barrier within.

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

How T cells lose their touch.

What counts in the immunological synapse?

CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation.

The immunological synapse.

Force and affinity in ligand discrimination by the TCR.

T cells have a light touch.

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria.

Agile CD22 nanoclusters run rings around fenced BCR.

Phagocytes Get Close to Their Enemies.

High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography.

CELL SIGNALING. Liquidity in immune cell signaling.

Tapping out a mechanical code for T cell triggering.

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Force Bistability in Adhesion Switch.

HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation.

Complement Receptors in Myeloid Cell Adhesion and Phagocytosis.

Help to go: T cells transfer CD40L to antigen-presenting B cells.

The Immune Synapse: Past, Present, and Future.

Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation.

Comprehensive Analysis of Immunological Synapse Phenotypes Using Supported Lipid Bilayers.

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity.

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer.

Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse.

A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering.

Distinct behavior of myelomonocytic cells and CD8 T cells underlies the hepatic response to .

Natural killers shed attachments to kill again.

Tumor Necrosis Factor Receptor Superfamily in T Cell Priming and Effector Function.

CD8 helps TCR catch slippery self pMHC.

CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity.

Integrins and Their Role in Immune Cell Adhesion.

An X-ray Vision for Phosphoantigen Recognition.

Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts.

Author Correction: Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity.

A checkpoint cliffhanger at the dawn of placental mammals.

Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells.

A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.

Author Correction: A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.

Locked and loaded: strong TCR signaling primes anti-PD-1 therapy.

The interplay between membrane topology and mechanical forces in regulating T cell receptor activity.

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor.

Magnesium for T cells: strong to the finish!