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Nepom Laboratory
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Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity.
Journal of autoimmunity Feb, 2002 | Pubmed ID: 11869047
Th2 dominance of T helper cell response to preproinsulin in individuals with preclinical type 1 diabetes.
Annals of the New York Academy of Sciences Apr, 2002 | Pubmed ID: 12021108
Relationship between T and B cell responses to proinsulin in human type 1 diabetes.
Annals of the New York Academy of Sciences Nov, 2003 | Pubmed ID: 14679078
CD28 costimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases.
Journal of immunological methods Feb, 2004 | Pubmed ID: 14980436
Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment.
Diabetes care May, 2004 | Pubmed ID: 15111548
T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading.
Journal of clinical immunology Jul, 2004 | Pubmed ID: 15163889
Increased in vivo frequency of IA-2 peptide-reactive IFNgamma+/IL-4- T cells in type 1 diabetic subjects.
Journal of autoimmunity Aug, 2004 | Pubmed ID: 15236752
Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.
Annals of the New York Academy of Sciences Dec, 2004 | Pubmed ID: 15699489
Experimental autoimmune diabetes: a new tool to study mechanisms and consequences of insulin-specific autoimmunity.
Annals of the New York Academy of Sciences Dec, 2004 | Pubmed ID: 15699519
Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls.
Clinical immunology (Orlando, Fla.) Apr, 2005 | Pubmed ID: 15870028
Immunological mechanisms associated with long-term remission of human type 1 diabetes.
Diabetes/metabolism research and reviews May-Jun, 2006 | Pubmed ID: 16222648
Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.
Diabetes Dec, 2005 | Pubmed ID: 16306335
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2006 | Pubmed ID: 16868084
The sentinel role of CD8 T cells in regulating CD4 T cell responses to proinsulin in beta-islet cell autoimmunity.
Annals of the New York Academy of Sciences Dec, 2008 | Pubmed ID: 19120311
Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis.
Gastroenterology Jul, 2010 | Pubmed ID: 20303356
Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative.
Diabetes/metabolism research and reviews Nov, 2011 | Pubmed ID: 22069252
Benaroya Research Institute
Eddie A. James1,
Rebecca LaFond2,
Ivana Durinovic-Bello3,
William Kwok2
1Tetramer Core Laboratory, Benaroya Research Institute,
2Kwok Laboratory, Benaroya Research Institute,
3Nepom Laboratory, Benaroya Research Institute
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