Kwok Laboratory
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Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis.
Arthritis and rheumatism Jan, 2002 | Pubmed ID: 11817597
HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.
Arthritis and rheumatism Jan, 2002 | Pubmed ID: 11817608
Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones.
Human immunology Mar, 2002 | Pubmed ID: 11872236
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.
Diabetes May, 2002 | Pubmed ID: 11978633
Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.
Journal of neuroimmunology May, 2002 | Pubmed ID: 12020970
HLA class II peptide-binding and autoimmunity.
Tissue antigens Feb, 2002 | Pubmed ID: 12028533
Defining antigen-specific responses with human MHC class II tetramers.
The Journal of allergy and clinical immunology Aug, 2002 | Pubmed ID: 12170258
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma.
The Journal of experimental medicine Sep, 2002 | Pubmed ID: 12208877
Use of class II tetramers for identification of CD4+ T cells.
Journal of immunological methods Oct, 2002 | Pubmed ID: 12213344
Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2003 | Pubmed ID: 12538679
HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells.
Clinical immunology (Orlando, Fla.) Jan, 2003 | Pubmed ID: 12584046
Challenges in staining T cells using HLA class II tetramers.
Clinical immunology (Orlando, Fla.) Jan, 2003 | Pubmed ID: 12584047
Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.
Methods (San Diego, Calif.) Mar, 2003 | Pubmed ID: 12725793
Low-avidity recognition by CD4+ T cells directed to self-antigens.
European journal of immunology May, 2003 | Pubmed ID: 12731068
P53(110-124)-specific human CD4+ T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8+ T cells.
Cancer research Jul, 2003 | Pubmed ID: 12839958
HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12960344
Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2.
Journal of virology Oct, 2003 | Pubmed ID: 14512540
Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.
Blood Feb, 2004 | Pubmed ID: 14563644
Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.
Annals of the New York Academy of Sciences Nov, 2003 | Pubmed ID: 14679042
HLA class II polymorphisms determine responses to bacterial superantigens.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2004 | Pubmed ID: 14734754
Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.
Diabetes Apr, 2004 | Pubmed ID: 15047612
Autoreactive T cells in healthy individuals.
Journal of immunology (Baltimore, Md. : 1950) May, 2004 | Pubmed ID: 15128778
Extensive replicative capacity of human central memory T cells.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2004 | Pubmed ID: 15153483
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
Diabetes Aug, 2004 | Pubmed ID: 15277377
In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of BirA enzyme for the generation of MHC class II/tetramers.
Human immunology Jul, 2004 | Pubmed ID: 15301857
Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2.
The Journal of infectious diseases Jan, 2005 | Pubmed ID: 15609235
Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2005 | Pubmed ID: 15749850
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
Blood Oct, 2005 | Pubmed ID: 16030184
Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells.
Human immunology Jul, 2005 | Pubmed ID: 16112025
Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells.
Journal of clinical immunology Sep, 2005 | Pubmed ID: 16160911
Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells.
International immunology Dec, 2005 | Pubmed ID: 16221722
The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.
European journal of immunology Nov, 2005 | Pubmed ID: 16245362
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.
Journal of autoimmunity Dec, 2005 | Pubmed ID: 16249070
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.
Journal of autoimmunity Nov, 2005 | Pubmed ID: 16263242
Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2006 | Pubmed ID: 16424231
Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.
Immunology Mar, 2006 | Pubmed ID: 16476054
Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2006 | Pubmed ID: 16493034
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.
The Journal of experimental medicine Apr, 2006 | Pubmed ID: 16585267
Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16585604
Multiplex mapping of CD4 T cell epitopes using class II tetramers.
Clinical immunology (Orlando, Fla.) Jul, 2006 | Pubmed ID: 16677863
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.
The Journal of clinical investigation Aug, 2006 | Pubmed ID: 16878175
Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2006 | Pubmed ID: 17082590
Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers.
Clinical immunology (Orlando, Fla.) Mar, 2007 | Pubmed ID: 17113829
CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65.
European journal of immunology Jan, 2007 | Pubmed ID: 17163450
Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.
Infection and immunity Apr, 2007 | Pubmed ID: 17283103
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy.
The Journal of allergy and clinical immunology Apr, 2007 | Pubmed ID: 17335888
Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus.
Journal of immunology (Baltimore, Md. : 1950) May, 2007 | Pubmed ID: 17475867
Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.
Molecular immunology Jan, 2008 | Pubmed ID: 17555819
Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition.
International immunology Nov, 2007 | Pubmed ID: 17906339
Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2007 | Pubmed ID: 17947711
Tracking antigen specific CD4+ T-cells with soluble MHC molecules.
Methods in molecular medicine , 2007 | Pubmed ID: 17983139
High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
Journal of virology Mar, 2008 | Pubmed ID: 18160439
Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis.
Molecular immunology Apr, 2008 | Pubmed ID: 18191206
Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2008 | Pubmed ID: 18209073
Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.
Molecular immunology May, 2008 | Pubmed ID: 18276010
Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection.
Journal of virology May, 2008 | Pubmed ID: 18337568
CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope.
Journal of autoimmunity Aug, 2008 | Pubmed ID: 18385016
Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.
Diabetes Jul, 2008 | Pubmed ID: 18586912
The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells.
Infection and immunity Oct, 2008 | Pubmed ID: 18678674
Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals.
International immunology Jan, 2009 | Pubmed ID: 19050106
Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.
European journal of immunology Feb, 2009 | Pubmed ID: 19180473
H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.
Vaccine Jun, 2009 | Pubmed ID: 19446935
Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.
Blood Aug, 2009 | Pubmed ID: 19549986
The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2009 | Pubmed ID: 19648278
Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.
Cancer research Oct, 2009 | Pubmed ID: 19808957
Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.
European journal of immunology Jan, 2010 | Pubmed ID: 19830726
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Journal of virology Apr, 2010 | Pubmed ID: 20071564
Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.
European journal of immunology Apr, 2010 | Pubmed ID: 20101615
HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.
PLoS pathogens Feb, 2010 | Pubmed ID: 20195518
Direct ex vivo analysis of allergen-specific CD4+ T cells.
The Journal of allergy and clinical immunology Jun, 2010 | Pubmed ID: 20513526
HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.
Arthritis and rheumatism Oct, 2010 | Pubmed ID: 20533291
Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses.
PloS one , 2010 | Pubmed ID: 20634998
Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy.
European journal of immunology Sep, 2010 | Pubmed ID: 20690179
Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis.
Hepatology (Baltimore, Md.) Oct, 2010 | Pubmed ID: 21190158
Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.
Journal of autoimmunity Mar, 2011 | Pubmed ID: 21257290
Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis.
Hepatology (Baltimore, Md.) Feb, 2011 | Pubmed ID: 21274874
Ara h 1-reactive T cells in individuals with peanut allergy.
The Journal of allergy and clinical immunology May, 2011 | Pubmed ID: 21459424
Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2011 | Pubmed ID: 21531896
Autoreactive CD4(+) T cells in patients with atopic dermatitis.
The Journal of allergy and clinical immunology Jul, 2011 | Pubmed ID: 21620451
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2011 | Pubmed ID: 21653833
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21765017
Human CD8⺠and CD4⺠T cell memory to lymphocytic choriomeningitis virus infection.
Journal of virology Nov, 2011 | Pubmed ID: 21900169
Differentiation stage determines pathologic and protective allergen-specific CD4(+) T-cell outcomes during specific immunotherapy.
The Journal of allergy and clinical immunology Feb, 2012 | Pubmed ID: 21975176
Induction and maintenance of allergen-specific FOXP3(+) Treg cells in human tonsils as potential first-line organs of oral tolerance.
The Journal of allergy and clinical immunology Feb, 2012 | Pubmed ID: 22051696
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.
PLoS pathogens Dec, 2011 | Pubmed ID: 22144893
DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9.
Molecular immunology Feb, 2012 | Pubmed ID: 22196942
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence.
The Journal of experimental medicine Jan, 2012 | Pubmed ID: 22213804
Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2012 | Pubmed ID: 22327072