Kazuhiro Oka

Recent advances in liver-directed gene therapy for dyslipidemia.

Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia.

Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice.

Liver-directed gene therapy for dyslipidemia and diabetes.

Targeting site-specific chromosome integration.

Inhibition and regression of atherosclerotic lesions.

Construction and characterization of helper-dependent adenoviral vectors for sustained in vivo gene therapy.

Regulatable atrial natriuretic peptide gene therapy for hypertension.

Essential role of Smad3 in angiotensin II-induced vascular fibrosis.

Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis.

Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice.

Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.

Helper-dependent adenoviral vectors.

Helper-dependent adenoviral vectors.

Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model.

Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity.

Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes.

A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins.

Direct observation of Gouy phase shift in a propagating optical vortex.

DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice.

ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene.

Liver-specific expression of an exogenous gene controlled by human apolipoprotein A-I promoter.

Interleukin-7 induces recruitment of monocytes/macrophages to endothelium.

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.