Gad Frankel

CesD2 of enteropathogenic Escherichia coli is a second chaperone for the type III secretion translocator protein EspD.

Polymorphisms within EspA filaments of enteropathogenic and enterohemorrhagic Escherichia coli.

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops.

Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma.

Functional analysis of the enteropathogenic Escherichia coli type III secretion system chaperone CesT identifies domains that mediate substrate interactions.

Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence.

Induction of cell death in T lymphocytes by invasin via beta1-integrin.

Enteropathogenic Escherichia coli translocate Tir and form an intimin-Tir intimate attachment to red blood cell membranes.

Coiled-coil proteins associated with type III secretion systems: a versatile domain revisited.

Efa1 influences colonization of the bovine intestine by shiga toxin-producing Escherichia coli serotypes O5 and O111.

Interaction of enteropathogenic Escherichia coli with red blood cell monolayers.

Tyrosine residues at the immunoglobulin-C-type lectin inter-domain boundary of intimin are not involved in Tir-binding but implicated in colonisation of the host.

CesT is a bivalent enteropathogenic Escherichia coli chaperone required for translocation of both Tir and Map.

Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli.

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins.

Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium.

Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences.

Host defences to Citrobacter rodentium.

3D structure of EspA filaments from enteropathogenic Escherichia coli.

Finding your niche: what has been learnt from STM studies on GI colonization.

Yeast two-hybrid system survey of interactions between LEE-encoded proteins of enteropathogenic Escherichia coli.

Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium.

CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB.

Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection.

Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture.

Enteropathogenic Escherichia coli (EPEC) adhesion to intestinal epithelial cells: role of bundle-forming pili (BFP), EspA filaments and intimin.

Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection.

SepL, a protein required for enteropathogenic Escherichia coli type III translocation, interacts with secretion component SepD.

Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli.

Interaction between protein subunits of the type IV secretion system of Bartonella henselae.

Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes.

Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene.

Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.

Distribution of espI among clinical enterohaemorrhagic and enteropathogenic Escherichia coli isolates.

TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton.

Regulators encoded in the Escherichia coli type III secretion system 2 gene cluster influence expression of genes within the locus for enterocyte effacement in enterohemorrhagic E. coli O157:H7.

Enteropathogenic Escherichia coli: unravelling pathogenesis.

EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics.

Interaction of enteropathogenic Escherichia coli with human intestinal mucosa: role of effector proteins in brush border remodeling and formation of attaching and effacing lesions.

Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ.

(1)H, (13)C, and (15)N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E. coli (EPEC).

Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion.

Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.

Molecular basis of antigenic polymorphism of EspA filaments: development of a peptide display technology.

Operon structure and gene expression of the espJ--tccP locus of enterohaemorrhagic Escherichia coli O157:H7.

Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells.

Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract.

Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence.

Structure of the bundle-forming pilus from enteropathogenic Escherichia coli.

Distribution of tccP in clinical enterohemorrhagic and enteropathogenic Escherichia coli isolates.

Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens.

Citrobacter rodentium of mice and man.

Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization.

The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium.

Role of intimin-tir interactions and the tir-cytoskeleton coupling protein in the colonization of calves and lambs by Escherichia coli O157:H7.

Subversion of actin dynamics by EPEC and EHEC.

Helicobacter pylori has stimulatory effects on naive T cells.

Modelling infectious disease - time to think outside the box?

Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium.

The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea.

EspF of enteropathogenic Escherichia coli binds sorting nexin 9.

A novel category of enteropathogenic Escherichia coli simultaneously utilizes the Nck and TccP pathways to induce actin remodelling.

Function and distribution of EspG2, a type III secretion system effector of enteropathogenic Escherichia coli.

Long polar fimbriae and tissue tropism in Escherichia coli O157:H7.

Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.

In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium.

Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157:H7.

An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination.

Comparison of colonization dynamics and pathology of mice infected with enteropathogenic Escherichia coli, enterohaemorrhagic E. coli and Citrobacter rodentium.

TccP2 of O157:H7 and non-O157 enterohemorrhagic Escherichia coli (EHEC): challenging the dogma of EHEC-induced actin polymerization.

Human intestinal tissue tropism in Escherichia coli O157 : H7--initial colonization of terminal ileum and Peyer's patches and minimal colonic adhesion ex vivo.

Adherence of enterohemorrhagic Escherichia coli O157, O26, and O111 strains to bovine intestinal explants ex vivo.

Vaccination of calves with EspA, a key colonisation factor of Escherichia coli O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation.

Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism.

Characterization of tccP2 carried by atypical enteropathogenic Escherichia coli.

Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models.

TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli.

Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents.

Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium.

A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium.

Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2.

Attaching effacing Escherichia coli and paradigms of Tir-triggered actin polymerization: getting off the pedestal.

In vivo imaging of gene transfer to the respiratory tract.

Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function.

EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis.

Genomic comparison of the O-antigen biosynthesis gene clusters of Escherichia coli O55 strains belonging to three distinct lineages.

Enterohemorrhagic Escherichia coli exploits EspA filaments for attachment to salad leaves.

Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens.

Structural and functional properties of chimeric EspA-FliCi filaments of EPEC.

Interaction of enterohemorrhagic Escherichia coli O157:H7 with mouse intestinal mucosa.

Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo.

The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.

Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.

RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium.

Interaction of Salmonella enterica with basil and other salad leaves.

Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.

EspT triggers formation of lamellipodia and membrane ruffles through activation of Rac-1 and Cdc42.

The mechanisms used by enteropathogenic Escherichia coli to control filopodia dynamics.

The role of doxorubicin in non-viral gene transfer in the lung.

Modelling of infection by enteropathogenic Escherichia coli strains in lineages 2 and 4 ex vivo and in vivo by using Citrobacter rodentium expressing TccP.

Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli.

Interactions of typical and atypical enteropathogenic Escherichia coli strains with the calf intestinal mucosa ex vivo.

Bioluminescent monitoring of in vivo colonization and clearance dynamics by light-emitting bacteria.

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo.

The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.

The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.

EspM2 is a RhoA guanine nucleotide exchange factor.

Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection.

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B.

Toward gene therapy for cystic fibrosis using a lentivirus pseudotyped with Sendai virus envelopes.

N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins.

Efa-1/LifA mediates intestinal colonization of calves by enterohaemorrhagic Escherichia coli O26 : H- in a manner independent of glycosyltransferase and cysteine protease motifs or effects on type III secretion.

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.

Fresh fruit and vegetables as vehicles for the transmission of human pathogens.

SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal.

Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins.

Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.

Direct injection of functional single-domain antibodies from E. coli into human cells.

Enteropathogenic and enterohemorrhagic Escherichia coli type III secretion effector EspV induces radical morphological changes in eukaryotic cells.

Fresh produce as a potential vector for bacterial human pathogens.

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation.

Salmonella enterica strains belonging to O serogroup 1,3,19 induce chlorosis and wilting of Arabidopsis thaliana leaves.

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.

Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux.

EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function.

The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner.

Salmonella bongori provides insights into the evolution of the Salmonellae.

PAK4 phosphorylates myosin regulatory light chain and contributes to Fcγ receptor-mediated phagocytosis.

Translation of a minigene in the 5' leader sequence of the enterohaemorrhagic Escherichia coli LEE1 transcription unit affects expression of the neighbouring downstream gene.

BopC is a type III secreted effector protein of Burkholderia pseudomallei.

Legionella pneumophila secretes a mitochondrial carrier protein during infection.

The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).

FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.

Infection strategies of enteric pathogenic Escherichia coli.

Recruitment and membrane interactions of host cell proteins during attachment of enteropathogenic and enterohaemorrhagic Escherichia coli.

Legionella pneumophila pathogenesis in the Galleria mellonella infection model.

Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity of infection.

EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation.

The motor protein myosin 1G functions in FcγR-mediated phagocytosis.

Subcellular localization of legionella Dot/Icm effectors.

The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi.

The Dot/Icm effector SdhA is necessary for virulence of Legionella pneumophila in Galleria mellonella and A/J mice.

Flagella mediate attachment of enterotoxigenic Escherichia coli to fresh salad leaves.

Cellulose mediates attachment of Salmonella enterica Serovar Typhimurium to tomatoes.

Interaction of enteroaggregative Escherichia coli with salad leaves.

Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors.

Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.

LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1.

A type III effector antagonizes death receptor signalling during bacterial gut infection.