Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity AssayIhsan Ekin Demir 1, Elke Tieftrunk 1, Karl-Herbert Schäfer 2, Helmut Friess 1, Güralp O. Ceyhan 1
1Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 2Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibrücken
Neuronal plasticity is an increasingly recognized, but insufficiently understood feature of the gastrointestinal (GI) tract. Here, in the example of human pancreatic disorders, we present an in vitro neuroplasticity assay for the study of neuronal plasticity in the GI tract at both morphological and functional level.