GlaxoSmithKline
2 ARTICLES PUBLISHED IN JoVE
Immunology and Infection
A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Jennifer L. Hoover 1, Thomas F. Lewandowski 1, Cindy L. Mininger 1, Christine M. Singley 1, Scott Sucoloski 1, Stephen Rittenhouse 1
1Antibacterial Discovery Performance Unit, GlaxoSmithKline
A method for establishing lung infections in immunocompetent rodents is described. With proficiency, this method can be performed quickly and easily to induce stable infection with many isolates of S. pneumoniae, H. influenzae, P. aeruginosa, K. pneumoniae and A. baumannii.
Biochemistry
An Open-Source Framework for Mass Calculation of Antibody-Based Therapeutic Molecules
Thomas Harkins 1,2, Li Cao 1, Kshitij Khatri 1,3
1GlaxoSmithKline, 2Merck, 3Moderna
This article describes the use of a software application, mAbScale, for the calculation of masses for monoclonal antibody-based protein therapeutics.
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