GlaxoSmithKline

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Jennifer L. Hoover¹, Thomas F. Lewandowski¹, Cindy L. Mininger¹, Christine M. Singley¹, Scott Sucoloski¹, Stephen Rittenhouse¹

¹Antibacterial Discovery Performance Unit, GlaxoSmithKline

A method for establishing lung infections in immunocompetent rodents is described. With proficiency, this method can be performed quickly and easily to induce stable infection with many isolates of S. pneumoniae, H. influenzae, P. aeruginosa, K. pneumoniae and A. baumannii.

Biochemistry

An Open-Source Framework for Mass Calculation of Antibody-Based Therapeutic Molecules

Thomas Harkins^1,2, Li Cao¹, Kshitij Khatri^1,3

¹GlaxoSmithKline, ²Merck, ³Moderna

This article describes the use of a software application, mAbScale, for the calculation of masses for monoclonal antibody-based protein therapeutics.