S'identifier

JoVE Journal

Medicine

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Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

9.4K Views

03:52 min

March 2nd, 2018

March 2nd, 2018

9,452 Views

0:05

Title

0:32

Procedure Setup

1:08

Surgical Approach

2:35

Results: Transduction of Utricular and Cochlear Hair Cells

3:22

Conclusion

Transcription

The overall goal of this procedure is to access the mouse inner ear for gene delivery. This method can help deliver gene therapy to the mouse inner ear in an efficient manner. The main advantages of this technique is that it's reliable and easy to

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In this study, we describe the posterior semicircular canal approach as a reliable method for inner ear gene delivery in neonatal mice. We show that gene delivery through the posterior semicircular canal is able to perfuse the entire inner ear.

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