Name: model surgical training: skills acquisition in fetoscopic laser photocoagulation of monochorionic diamniotic twin placenta using realistic simulators
Uploaded: 2018-03-21T14:00:00
Description: Watch this Scientific Journal Video about Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators Video at

The authors would like to thank the people who have helped with building the models, providing materials, and facilitating training workshops in Singapore and Bangkok: Dr. Ying Woo Ng, Prof. Yoke Fai Fong, Sommai Viboonchart, Ginny Chen, Cecile Laureano, Pei Huang Kuan, Mei Lan Xie, Prof. Jerry KY Chan. Materials were supported by the Obstetrics and Gynaecology departments of Faculty of Medicine Siriraj Hospital, Bangkok and the National University Hospital, Singapore, and by National Medical Research Council (Singapore) grant NMRC/CSA/043/2012.

The collection of human placenta from term deliveries was approved by the Domain Specific Review Board of the NUH of Singapore (DSRB C/00/524) and by the Siriraj Institutional Review Board (SIRB 704/2559) of Siriraj Hospital in Bangkok. In all cases, patients gave separate informed written consent for the use of the collected specimen. The pig bladders were collected from a local butcher in Singapore and were a kind donation from Dr. Ying Woo Ng (NUH). The non-human primate (NHP) placentas were waste material collected f...

The skills practiced on a fetoscopy simulator and on the tissue models encompass the majority of technical abilities required for SFLP. The advantages of training on these models include learning to simultaneously handle the ultrasound probe and fetoscope, familiarity with handling the straight and curved fetoscopes, practicing the systematic examination of the vascular equator along the whole length of the inter-twin membrane to identify anastomosing vessels on high-fidelity MCDA placenta, and learning the correct techn...

The acquisition of a new, minimally-invasive surgical technique often employs the traditional surgical apprenticeship model in which an individual learns from observing an expert surgeon operate on a live patient and eventually performs the technique under close supervision1. This time-honored model often limits the passage of knowledge from mentor to individual trainee and relies heavily on the availability of resources such as training funds and patient case-load2. Fetoscopic surgery is an example of a high-risk minimally-invasive surgery, performed on a preterm individual during pregnancy in which there are risks to both the mother and fetus. As with any surgical procedure, higher complication rates arise at the initial steep slope of the learning curve. Thus, surgeries are usually performed by the most senior or skilled surgeon in order to meet the critical volume of cases to optimize patient outcomes3.
Good fetoscopy skills are important for the future of fetal therapy, which strives to be minimally invasive, even with respect to the correction of structural defects4,5,6. Fetoscopic surgery is technically challenging and there are inherent risks to patient safety associated with practicing and developing new skills in the real-life theater environment. Even established surgeons require time and consistent practice on multiple patients to acquire expertise, skills in troubleshooting when difficulties arise, and the instinct to predict and avoid pitfalls in a new and complex procedure. There is less tolerance for suboptimal outcomes usually associated with novice proceduralists7. While it is important not to compromise patient safety during the initial implementation of fetoscopic surgery, there is also a need to enhance the efficiency with which skills and expertise are acquired by all proceduralists, particularly in smaller clinical units just beginning to practice fetoscopy. An alternative system complementary to traditional apprenticeship is needed to meet the challenges of limited training funds and a small patient base on which to master these highly specialized procedures. Procedural learning curves can be shortened, and complications reduced by training on high-fidelity machines or cadaveric animal models, with dedicated traditional mentoring or distant proctorship and procedure-focused stepwise learning8,9,10,11. Familiarization with the fetoscope manipulation, intrauterine orientation of the vascular equator, and laser coagulation before performing the actual surgery has the potential to reduce operative complications12,13. This training may shorten the learning curve for new operators as they master basic skills on a realistic tissue model.
Monozygotic twinning occurs with uniform frequency worldwide affecting 3-5 per 1,000 pregnancies, and the 75% of monozygotic twins with monochorionic diamniotic (MCDA) placentation are at significant risk for TTTS, which currently complicates about 10-15% of MCDA pregnancies, or 1-3 per 10,000 births14. The incidence is expected to increase with the frequency of in vitro fertilization (IVF) in which there is a 2 to 12-fold increase in monozygosity15,16,17,18,19. TTTS arises from unidirectional inter-fetal blood flow via deep intraplacental AVA. Untreated, this carries a 60-100% mortality and significant morbidity for surviving fetuses20,21,22.
Selective fetoscopic laser coagulation (SFLP) is the only curative intervention aimed at the rescue of both twins via fetoscopic identification and ablation of the offending AVA, and is considered the standard of care in TTTS stages II-IV (~ 93% of all cases) in pregnancies at &#60; 26 weeks of gestation, with clinical studies in progress to determine if it should also be applied to selected stage I disease23,24,25. SFLP carries an overall perinatal survival of ~ 70% with a higher likelihood of more advanced gestation and higher birth weights at delivery26,27 and is considered superior to other interventions as it directly rectifies the underlying pathology of TTTS28,29,30. The intervention itself is not without complications, and laser-treated TTTS is associated with recurrence (0-16%), perinatal mortality (~ 35%), and a 5-20% chance of long-term neurologic handicap23. Acquisition of the correct skills, building expertise over a steep learning curve, adherence to international standards of fetoscopic practice, and maintaining surgical dexterity are essential to providing the best outcomes in this complex disease13,31,32,33. This is often dependent on financial and human resources and a critical volume of cases that may take significant time to acquire34. Established fetal therapy centers are currently concentrated in Western Europe and North America, but the predicted population boom (and thus new pregnancies) will mostly affect Asia and Africa35,36. Therefore, an increase in the incidence of fetal anomalies amenable to intrauterine treatment can be expected in these lower-resource populations. The dissemination of specialized services such as fetoscopic surgery is a challenge that needs to be addressed as a regional priority37. New fetal therapy centers in these regions must reliably provide SFLP services to meet the needs of their communities, but significant investment and time is needed for new centers to achieve equivalent outcomes as established ones38,39,40,41.
Departing from the resource-heavy apprenticeship model will facilitate a much-needed dissemination of skills and expertise to communities in which there is a great demand for it. The traditional surgical apprenticeship is still relevant but less practical for many smaller clinical units, as it is time- and resource-consuming and limits the passage of knowledge and skills to one trainee at a time. Simulator training under proctorship is more applicable on a wider scale and facilitates the passage of knowledge and skills passed from one expert to multiple persons through workshops and regular skills training on reliable tissue models13,42,43. It has been suggested that, because of its rarity, TTTS treatment should be accumulated in high-volume fetal centers to improve its outcomes. Yet, there is also a need to establish new fetal care centers to improve patient access to treatment. Emerging fetal care centers, like the National University Hospital in Singapore (NUH), will need to adhere to certain guidelines in order to maintain their surgical outcomes, i.e., Siriraj-NUH proctorship system as seen in Figure 137.
In this article we will describe a model-based system with which new proceduralists can undergo skills training in tandem under the guidance of an expert proctor, and by which skills can be practiced to maintain surgical dexterity during long intervals between patients. We will share practical points from our experiences at the Siriraj Hospital in Bangkok and the NUH in Singapore in initiating fetal therapy6,44,45.

<table border="0" cellpadding="0" cellspacing="0" style="width:1253px;" width="1253">
	<colgroup>
		<col span="2" />
		<col />
		<col />
	</colgroup>
	<tbody>
		<tr height="84">
			<td height="84" style="height:85px;width:215px;">Fetoscopic Simulator</td>
			<td style="width:215px;">Maternal-Fetal Medicine unit, Department of Obstetrics and Gynaecology, Siriraj Hospital, Bangkok, Thailand</td>
			<td style="width:367px;">NA.</td>
			<td style="width:457px;">Siriraj Fetoscopic Simulator. Customised model of monochorionic anterior/posterior placenta and anastomses produced at the Siriraj Hospital in Bangkok.</td>
		</tr>
		<tr height="66">
			<td height="66" style="height:67px;width:215px;">Laparoscopy tower with light source, camera and video recorder</td>
			<td style="width:215px;">Olympus Singapore</td>
			<td style="width:367px;">Olympus Visera Elite system (Olympus Singapore) with camera OTV-S190 and light source CLV-S190 set at medium intensity (level 0) and video recorder&#160;</td>
			<td style="width:457px;">Laparoscopy tower for fetoscopy and recording of practice</td>
		</tr>
		<tr height="64">
			<td height="64" style="height:64px;width:215px;">Voluson E8 ultrasound machine with 4CD probe</td>
			<td style="width:215px;">GE Healthcare Singapore</td>
			<td style="width:367px;">GE Voluson E8; transabdominal 4CD curved transducer (2-5MHz)&#160;</td>
			<td style="width:457px;">Ultrasound system for guidance of fetoscope introduction and manipulation</td>
		</tr>
		<tr height="60">
			<td height="60" style="height:60px;width:215px;">Minature straight forward telescope 0o (2mm) for posterior placenta</td>
			<td style="width:215px;">KARL STORZ GmbH &#38; Co KG, Tuttlingen, Germany</td>
			<td style="width:367px;">11630AA</td>
			<td style="width:457px;">Fetoscope. 0&#176; lens, diameter 2mm, length 26cm, autoclavable, fibre optic light transmission incorporated. To use with operating sheath 11630KF.</td>
		</tr>
		<tr height="85">
			<td height="85" style="height:86px;width:215px;">Operating sheath, straight with pyramidal obturator.&#160;</td>
			<td style="width:215px;">KARL STORZ GmbH &#38; Co KG, Tuttlingen, Germany</td>
			<td style="width:367px;">11630 KF</td>
			<td style="width:457px;">Size 9 Fr with working channel 1 mm, for use with 11630AA; working channel for laser fibres up to 400&#181;m core.</td>
		</tr>
		<tr height="77">
			<td height="77" style="height:78px;width:215px;">Multichannel miniature straight forward telescope 0&#176; set straight for posterior placenta</td>
			<td style="width:215px;">KARL STORZ GmbH &#38; Co KG, Tuttlingen, Germany</td>
			<td style="width:367px;">11506AAK</td>
			<td style="width:457px;">Fetoscope. 0&#176; lens, diameter 3.3 mm, length 30cm , 30,000 pixels, integrated channels, autoclavable, fibre optic light transmission incorporated.&#160;</td>
		</tr>
		<tr height="77">
			<td height="77" style="height:78px;width:215px;">Multichannel miniature straight forward telescope 0&#176; set curved&#160; for anterior placenta</td>
			<td style="width:215px;">KARL STORZ GmbH &#38; Co KG, Tuttlingen, Germany</td>
			<td style="width:367px;">11508AAK</td>
			<td style="width:457px;">Fetoscope. 0&#176; lens, diameter 3.3 mm, length 30cm , 30,000 pixels, integrated channels, autoclavable, fibre optic light transmission incorporated.&#160;</td>
		</tr>
		<tr height="77">
			<td height="77" style="height:78px;width:215px;">Dornier diode laser with 400um or 600um laser fibre</td>
			<td style="width:215px;">Medilas D Multibeam, Dornier MedTech Asia, Singapore</td>
			<td style="width:367px;">S/N D60-353</td>
			<td style="width:457px;">Laser photocoagulation system. Diode (30-60 W)&#160;</td>
		</tr>
		<tr height="77">
			<td height="77" style="height:78px;width:215px;">Laser fibre&#160;</td>
			<td style="width:215px;">400-600&#181;m laser fiber</td>
			<td style="width:367px;">Disposable LG type D01-6080-BF-0;LOT 1024/0613</td>
			<td style="width:457px;">Use the provided ceramic cutter to refashion the tip of the fibre once coagulated after burning to maintain the sharp focus of the laser.&#160;</td>
		</tr>
		<tr height="77">
			<td height="77" style="height:78px;width:215px;">Large plastic container with ultrasound transparent skin;</td>
			<td style="width:215px;">NA</td>
			<td style="width:367px;">NA.</td>
			<td style="width:457px;">Container is a simple houshold item with a watertight lid that cn be locked in place. The silicon rubber &#34;skin&#34; produced inhouse allows US visualisation of the placenta within the container. Can be used as a simulator for vascular laser coagulation.&#160;</td>
		</tr>
		<tr height="77">
			<td height="77" style="height:78px;width:215px;">Pig bladder and small mid-gestation placenta&#160;</td>
			<td style="width:215px;">NA</td>
			<td style="width:367px;">NA.</td>
			<td style="width:457px;">Obtained from the local butcher. Elastic tissue that can be stretched when filled with large volume of fluid; can incorporate a small human/NHP placenta and used as a simulator for laser coagulation&#160;</td>
		</tr>
	</tbody>
</table>

model surgical training: skills acquisition in fetoscopic laser photocoagulation of monochorionic diamniotic twin placenta using realistic simulators

Fetoscopic laser coagulation of arterio-venous anastomoses (AVA) in a monochorionic placenta is the standard of care for twin-twin transfusion syndrome (TTTS), but is technically challenging and can lead to significant complications. Acquiring and maintaining the necessary surgical skills require consistent practice, a critical caseload, and time. Training on realistic surgical simulators can potentially shorten this steep learning curve and enables several proceduralists to acquire procedure-specific skills simultaneously. Here we describe realistic simulators designed to allow the user familiarity with the equipment and specific steps required in the surgical treatment of TTTS, including fetoscopic handling, approaches to anterior and posterior placenta, recognition of anastomoses, and efficient coagulation of vessels. We describe the skills that are especially important in conducting placental laser coagulation that the surgeon can practice on the model and apply in a clinical case. These models can be adapted easily depending on the availability of materials and require standard fetoscopy equipment. Such training systems are complementary to traditional surgical apprenticeships and can be useful aids for fetal medicine units that provide this clinical service.

The basic requirements for a fetoscopy simulator are a transparent &#34;skin&#34; that enables ultrasound visualization of the placenta within the model and a representative model of the MCDA placenta. The simulator illustrated here was developed at Siriraj Hospital (Bangkok), and is a closed system that incorporates a silicon replica of a mid-gestation monochorionic placenta (Figure 1). The consistent use of this model should increase the confidence of the n...

Watch this Scientific Journal Video about Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators Video at

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators Video (Video) | JoVE

Practicing the specific skills required for fetoscopic laser coagulation of monochorionic placental anastomoses on realistic models can aid less experienced surgeons in overcoming the steep learning curve associated with this procedure that is now regarded as the standard of care for twin-twin transfusion syndrome.

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Fetoscopic laser coagulation of arterio-venous anastomoses (AVA) in a monochorionic placenta is the standard of care for twin-twin transfusion syndrome ...

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