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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

DOI :

10.3791/60360-v

February 10th, 2020

February 10th, 2020

9,782 Views

1Fralin Biomedical Research Institute at Virginia Tech Carilion, 2School of Neuroscience, Virginia Tech, 3Department of Biological Sciences, Virginia Tech

This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition systems.

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