Quantitative Measurement of Osteoarthritic Subchondral Bone with ImageJ Software
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Statistics
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Representative Results
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Conclusion
Transcription
Subchondral bone thickening, or sclerosis, is one of the hallmarks of osteoarthritis, both in animal models and in humans. Currently, the severity of histologic subchondral bone thickening is mostly determined by visual estimation based on semi-qu
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This methodology article presents a software-assisted quantitative measurement protocol to quantify histologic subchondral bone thickness in murine osteoarthritic knee joints and normal knee joints as controls. This protocol is highly sensitive to subtle thickening and is suitable for detecting early osteoarthritic subchondral bone changes.