Owen J.T. McCarty

Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis.

Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells.

Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.

Evaluation of platelet antagonists in in vitro flow models of thrombosis.

Preferential binding of platelets to monocytes over neutrophils under flow.

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.

Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin.

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

Minimal regulation of platelet activity by PECAM-1.

The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen.

Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody.

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.

Distinct extracellular matrix microenvironments of progenitor and carotid endothelial cells.

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells.

Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.

Single particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis.

Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).

Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow.

Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress.

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.

Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates.

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.

Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype.

Breakup feared after filamin leaves GPIb.

Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke.

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.

Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes.

Platelet shape change and spreading.

Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography.

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis.

Regulation of the mTOR-Rac1 axis in platelet function.

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient.

Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis.

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

Development of coagulation factor probes for the identification of procoagulant circulating tumor cells.

Do circulating tumor cells play a role in coagulation and thrombosis?

Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope.

Modeling and simulation of procoagulant circulating tumor cells in flow.

Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation.

Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.

Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice.

Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease.

Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy.

Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor.

Development of a Label-free Imaging Technique for the Quantification of Thrombus Formation.

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice.

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.

Microfluidics and coagulation biology.

Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy.

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear.

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.

Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation.

A theme series on physical biology in cancer in AJP-Cell.

Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells.

Physical biology in cancer. 2. The physical biology of circulating tumor cells.

Rac and Cdc42 team up for platelets.

Factor XII inhibition reduces thrombus formation in a primate thrombosis model.

Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer.

Measurement science in the circulatory system.