Keizo Takao

Ionic basis of cold receptors acting as thermostats.

Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.

Targeting quantum dots to surface proteins in living cells with biotin ligase.

Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice.

Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders.

Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes.

[Investigating genes-to-behavior pathways in psychiatric diseases: an approach using a comprehensive behavioral test battery on genetically engineered mice].

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

Comprehensive behavioral phenotyping of calpastatin-knockout mice.

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.

Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior.

Normal mitochondrial respiratory function is essential for spatial remote memory in mice.

Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.

Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice.

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.

Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities.

Intrauterine environment-genome interaction and children's development (4): Brain-behavior phenotypying of genetically-engineered mice using a comprehensive behavioral test battery on research of neuropsychiatric disorders.

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice.

KF-1 Ubiquitin Ligase: An Anxiety Suppressor.

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.

Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.

SDOP-DB: a comparative standardized-protocol database for mouse phenotypic analyses.

Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.

[Immature dentate gyrus as a candidate endophenotype of psychiatric disorders].

Behavioral profiles of three C57BL/6 substrains.

Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test.

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus.

Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors.

[Genes, behaviors and psychiatric disorders].

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling.

The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice.

Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.

Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory.

P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating.

Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior.

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles.

Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits.

Increased astrocytic ATP release results in enhanced excitability of the hippocampus.

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice.

Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice.

Behavioral abnormalities observed in Zfhx2-deficient mice.

Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly.

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.

ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response.

Immature dentate gyrus: an endophenotype of neuropsychiatric disorders.

Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.

Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.

PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.

Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition.

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.

Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice.

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.

Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes.

Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia.

Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus.

Mechanisms for interferon-α-induced depression and neural stem cell dysfunction.

[Immaturity of brain as an endophenotype of neuropsychiatric disorders].

Genomic responses in mouse models greatly mimic human inflammatory diseases.

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours.

Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important.