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Department of Neuroscience,
Center for Translational Research in Neurodegenerative Disease,
Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease
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Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures.
Biochemical pharmacology Jan, 2002 | Pubmed ID: 11754870
Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12058035
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2003 | Pubmed ID: 12670874
Early and late molecular events in neurodegeneration and neuroprotection in Parkinson's disease MPTP model as assessed by cDNA microarray; the role of iron.
Neurotoxicity research Nov-Dec, 2002 | Pubmed ID: 12709306
Neuroprotective strategies in Parkinson's disease : an update on progress.
CNS drugs , 2003 | Pubmed ID: 12873156
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.
The Journal of clinical investigation Jan, 2006 | Pubmed ID: 16341263
Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.
Journal of neuroinflammation , 2006 | Pubmed ID: 16872492
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2006 | Pubmed ID: 17068112
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2006 | Pubmed ID: 17108166
Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2007 | Pubmed ID: 17611268
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18524908
Quantitative and mechanistic studies of Abeta immunotherapy.
CNS & neurological disorders drug targets Mar, 2009 | Pubmed ID: 19275635
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2009 | Pubmed ID: 19638957
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2010 | Pubmed ID: 19825975
Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
Journal of molecular biology Jan, 2011 | Pubmed ID: 21073877
Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP.
Journal of Alzheimer's disease : JAD , 2012 | Pubmed ID: 22156046
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.
Alzheimer's research & therapy , 2012 | Pubmed ID: 22621179
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo.
Nature communications , 2012 | Pubmed ID: 22910355
Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo.
The European journal of neuroscience Apr, 2013 | Pubmed ID: 23347239
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Acta neuropathologica Jul, 2013 | Pubmed ID: 23666556
Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.
PloS one , 2013 | Pubmed ID: 23825679
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.
Acta neuropathologica communications , 2013 | Pubmed ID: 24252149
University of Florida
Ji-Yoen Kim*,1,
Stacy D. Grunke*,1,
Yona Levites2,
Todd E. Golde2,
Joanna L. Jankowsky1,3
1Department of Neuroscience, Baylor College of Medicine,
2Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida,
3Department of Neurology and Department of Neurosurgery, Baylor College of Medicine
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