Marc E. Rothenberg

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.

Eosinophilic gastrointestinal disorders (EGID).

Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways.

Foxa2 regulates alveolarization and goblet cell hyperplasia.

Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9).

Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.

Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis.

T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice.

Eosinophilic esophagitis.

VEGF obstructs the lungs.

Arginine in asthma and lung inflammation.

Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma.

Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection.

Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation.

Expression and regulation of small proline-rich protein 2 in allergic inflammation.

Molecular mechanisms of anaphylaxis: lessons from studies with murine models.

CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.

Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1.

Suppressive effect of IL-4 on IL-13-induced genes in mouse lung.

Anti-IL-5 and hypereosinophilic syndromes.

Eliminating eosinophilic esophagitis.

Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort study.

Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice.

The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia.

Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity.

Eosinophilic esophagitis.

The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease.

Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.

The arginine-arginase balance in asthma and lung inflammation.

Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders.

IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.

The eosinophil.

Persistent effects induced by IL-13 in the lung.

Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.

ICAM-1-dependent pathways regulate colonic eosinophilic inflammation.

Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.

The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection.

CD48 is an allergen and IL-3-induced activation molecule on eosinophils.

Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses.

Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.

Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens.

Quantity and distribution of eosinophils in the gastrointestinal tract of children.

Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.

Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.

Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis.

A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation.

Eosinophilic esophagitis: pathogenesis, genetics, and therapy.

A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis.

Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.

Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.

Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung.

Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice.

Pediatric patients with eosinophilic esophagitis: an 8-year follow-up.

CD48 is critically involved in allergic eosinophilic airway inflammation.

Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.

Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance.

Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.

Eosinophils in the new millennium.

Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung.

Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis.

Gastrointestinal eosinophilia.

Summary of the First International Gastrointestinal Eosinophil Research Symposium.

An eosinophil hypothesis for functional dyspepsia.

Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.

Basic pathogenesis of eosinophilic esophagitis.

IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.

Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia.

A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.

Treatment of patients with the hypereosinophilic syndrome with mepolizumab.

IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasis.

Surfactant protein D alters allergic lung responses in mice and human subjects.

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity.

Eosinophils: biological properties and role in health and disease.

Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.

2007 E. Mead Johnson award: scientific pursuit of the allergy problem.

Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases.

Origin, regulation and physiological function of intestinal oeosinophils.

Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.

FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome.

Allergy and eosinophil-associated gastrointestinal disorders (EGID).

Mitochondrial missile defense.

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.

Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea.

Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis.

Chemotactic factors associated with eosinophilic gastrointestinal diseases.

Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade.

Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis.

Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation.

Biology of the eosinophil.

Molecular diagnostics and treatment of patients with the hypereosinophilic syndrome.

MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression.

Eosinophilic esophagitis: concepts, controversies, and evidence.

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.

Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia.

CCR3 is a target for age-related macular degeneration diagnosis and therapy.

Biology and treatment of eosinophilic esophagitis.

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.

Hypersensitivity and allergy: from mice to men.

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.

Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.

Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.

Persistent rotavirus vaccine shedding in a new case of severe combined immunodeficiency: A reason to screen.

Health-related quality of life across pediatric chronic conditions.

Importance of cytokines in murine allergic airway disease and human asthma.

Key advances in mechanisms of asthma, allergy, and immunology in 2009.

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.

Common variants at 5q22 associate with pediatric eosinophilic esophagitis.

Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51.

Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice.

Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract.

Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.

Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice.

Hypereosinophilic syndromes and new therapeutic approaches including anti-IL-5.

Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.

IL-5 pathway inhibition in the treatment of asthma and Churg-Strauss syndrome.

Involvement of mast cells in eosinophilic esophagitis.

IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.

The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis.

Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999.

Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis.

Refining the definition of hypereosinophilic syndrome.

Innate sensing of nickel.

Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies.

IL-13Rα2 has a protective role in a mouse model of cutaneous inflammation.

TGF-β1: Mediator of a feedback loop in eosinophilic esophagitis--or should we really say mastocytic esophagitis?

The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice.

A striking local esophageal cytokine expression profile in eosinophilic esophagitis.

Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.

Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation.

Advances in mechanisms of asthma, allergy, and immunology in 2010.

Differences in candidate gene association between European ancestry and African American asthmatic children.

Eosinophilic esophagitis: updated consensus recommendations for children and adults.

Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.

Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders.

Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies.

Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2.

Long-term outcomes in pediatric-onset esophageal eosinophilia.

MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity.

IL-13 receptor α1 differentially regulates aeroallergen-induced lung responses.

Eosinophilic esophagitis: rapidly advancing insights.

Treatment adherence in pediatric eosinophilic gastrointestinal disorders.

Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods.

The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia.

Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial.

Resistin-like molecule-α regulates IL-13-induced chemokine production but not allergen-induced airway responses.

Advances in mechanisms of asthma, allergy, and immunology in 2011.

MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers.

Behavioral functioning and treatment adherence in pediatric eosinophilic gastrointestinal disorders.

Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis.

The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research.

Behavioral feeding problems and parenting stress in eosinophilic gastrointestinal disorders in children.

Novel targeted therapies for eosinophilic disorders.

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).

Working with the US Food and Drug Administration: progress and timelines in understanding and treating patients with eosinophilic esophagitis.

Development of the Pediatric Quality of Life Inventory™ Eosinophilic Esophagitis module items: qualitative methods.

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes.

Reply: To PMID 22541246.

Commentary on "Markers of Antigen Presentation And Activation On Eosinophils And T-Cells in the Esophageal Tissue of Patients With Eosinophilic Esophagitis"

The Child Health Research Centers: twenty-one years of promoting the development of pediatrician scientists from 1990-2011.

ICON: Eosinophil Disorders.

MiR-223 deficiency increases eosinophil progenitor proliferation.

Targeting eosinophils in allergy, inflammation and beyond.

Advances in mechanisms of allergy and clinical immunology in 2012.

PedsQL eosinophilic esophagitis module: feasibility, reliability, and validity.

Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth.

Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.

Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitis.

High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders.

Current concepts on the pathogenesis of the hypereosinophilic syndrome/chronic eosinophilic leukemia.

Expanding the paradigm of eosinophilic esophagitis: mast cells and IL-9.

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.

Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.

Molecular diagnosis of eosinophilic esophagitis by gene expression profiling.

IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.

Eosinophilic asthma: insights into the effects of reducing IL-5 receptor-positive cell levels.

Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.

Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis.

Demethylation of the human eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3.

Increased prevalence of eosinophilic gastrointestinal disorders in pediatric PTEN hamartoma tumor syndromes.

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities.

The management of eosinophilic esophagitis.

Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis.

Eosinophils and cancer.

Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease.

Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.

Genetic and epigenetic underpinnings of eosinophilic esophagitis.

Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFRα initiated chronic eosinophilic leukemia/systemic mastocytosis.

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.

Roles and regulation of gastrointestinal eosinophils in immunity and disease.

Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.

IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation.

Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.

Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.

Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis.

Making it big in allergy.

Resistin-like Molecule Alpha in Allergen-induced Pulmonary Vascular Remodeling.