Institute for Brain Aging and Dementia
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A P-insertion screen identifying novel X-linked essential genes in Drosophila.
Mechanisms of development Jan, 2002 | Pubmed ID: 11744370
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus.
Genetics Feb, 2002 | Pubmed ID: 11861561
Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man.
Cell Jul, 2002 | Pubmed ID: 12150923
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome.
Neuroscience letters Sep, 2002 | Pubmed ID: 12213643
Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development.
Development (Cambridge, England) Feb, 2003 | Pubmed ID: 12490563
Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice.
Neuroscience letters Feb, 2003 | Pubmed ID: 12565127
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.
Neurochemical research Feb, 2003 | Pubmed ID: 12608703
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.
International immunology Apr, 2003 | Pubmed ID: 12663680
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.
Neurobiology of disease Apr, 2003 | Pubmed ID: 12742739
Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumors.
Clinical & experimental metastasis , 2003 | Pubmed ID: 14598882
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene.
European journal of immunology Dec, 2003 | Pubmed ID: 14635031
Caspase-mediated degeneration in Alzheimer's disease.
The American journal of pathology Aug, 2004 | Pubmed ID: 15277211
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome.
Neuron Aug, 2004 | Pubmed ID: 15294141
Mimotopes of conformational epitopes in fibrillar beta-amyloid.
Journal of neuroimmunology Nov, 2004 | Pubmed ID: 15465592
Patterned cell culture inside microfluidic devices.
Lab on a chip Jan, 2005 | Pubmed ID: 15616747
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2005 | Pubmed ID: 15661919
Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.
Developmental biology Feb, 2005 | Pubmed ID: 15680366
A microfluidic culture platform for CNS axonal injury, regeneration and transport.
Nature methods Aug, 2005 | Pubmed ID: 16094385
Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.
Journal of neuroinflammation , 2005 | Pubmed ID: 16332263
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.
Vaccine Mar, 2006 | Pubmed ID: 16368167
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.
Vaccine Apr, 2006 | Pubmed ID: 16460841
Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant.
Journal of cellular biochemistry Aug, 2006 | Pubmed ID: 16741971
Novel approaches for immunotherapeutic intervention in Alzheimer's disease.
Neurochemistry international Jul, 2006 | Pubmed ID: 16765487
The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways.
Development genes and evolution Jul-Aug, 2006 | Pubmed ID: 16773339
Relapsing polychondritis with features of dementia with Lewy bodies.
Acta neuropathologica Aug, 2006 | Pubmed ID: 16832629
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
The Journal of biological chemistry Dec, 2006 | Pubmed ID: 17056594
External force-assisted cell positioning inside microfluidic devices.
Biomedical microdevices Feb, 2007 | Pubmed ID: 17091393
Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates.
DNA and cell biology Oct, 2006 | Pubmed ID: 17132088
Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17182597
Distinct roles for Mediator Cdk8 module subunits in Drosophila development.
The EMBO journal Feb, 2007 | Pubmed ID: 17290221
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
The Journal of biological chemistry Aug, 2007 | Pubmed ID: 17545160
Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease.
Journal of Alzheimer's disease : JAD Jul, 2007 | Pubmed ID: 17656824
Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization.
DNA and cell biology Jan, 2008 | Pubmed ID: 17961074
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2007 | Pubmed ID: 18003852
Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2007 | Pubmed ID: 18057195
Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).
Neurochemistry international May, 2008 | Pubmed ID: 18079022
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2008 | Pubmed ID: 18385314
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.
Journal of neuroinflammation , 2008 | Pubmed ID: 18400101
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
PloS one , 2008 | Pubmed ID: 18461171
Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster.
Development (Cambridge, England) Jul, 2008 | Pubmed ID: 18508864
Cross-regulatory protein-protein interactions between Hox and Pax transcription factors.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18755899
Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.
Journal of neuroinflammation , 2008 | Pubmed ID: 18823564
Gene expression changes in the course of normal brain aging are sexually dimorphic.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2008 | Pubmed ID: 18832152
DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype.
Journal of neuroimmunology Dec, 2008 | Pubmed ID: 18838175
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2008 | Pubmed ID: 19020010
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I.
CNS & neurological disorders drug targets Mar, 2009 | Pubmed ID: 19275632
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part II.
CNS & neurological disorders drug targets Apr, 2009 | Pubmed ID: 19355929
A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.
Acta neuropathologica Oct, 2009 | Pubmed ID: 19360426
Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2009 | Pubmed ID: 19439591
Abeta DNA vaccination for Alzheimer's disease: focus on disease prevention.
CNS & neurological disorders drug targets Apr, 2010 | Pubmed ID: 20205639
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.
Neurobiology of disease Sep, 2010 | Pubmed ID: 20451612
Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.
Human gene therapy Nov, 2010 | Pubmed ID: 20528468
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20555131
Microfluidic Multicompartment Device for Neuroscience Research.
Langmuir : the ACS journal of surfaces and colloids Mar, 2003 | Pubmed ID: 20725530
Anti-11[E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: relevance for immunotherapy.
Journal of neuroimmunology Dec, 2010 | Pubmed ID: 20864186
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.
Annals of the New York Academy of Sciences Oct, 2010 | Pubmed ID: 20955427
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.
Molecular immunology Nov-Dec, 2010 | Pubmed ID: 20970857
An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.
Neurobiology of aging May, 2011 | Pubmed ID: 21546126
Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma.
Cellular immunology , 2011 | Pubmed ID: 21641588
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
The American journal of pathology Aug, 2011 | Pubmed ID: 21704011
Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy.
Stroke; a journal of cerebral circulation Nov, 2011 | Pubmed ID: 21903962
Frontal Cortex Neuropathology in Dementia Pugilistica.
Journal of neurotrauma Oct, 2011 | Pubmed ID: 22017610
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
PloS one , 2011 | Pubmed ID: 22046234
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22095718
Delivery of a DNA Vaccine for Alzheimer's Disease by Electroporation versus Gene Gun Generates Potent and Similar Immune Responses.
Neuro-degenerative diseases Feb, 2012 | Pubmed ID: 22301697