David Cribbs

A P-insertion screen identifying novel X-linked essential genes in Drosophila.

The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus.

Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man.

Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome.

Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development.

Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice.

The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.

Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.

Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumors.

Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene.

Caspase-mediated degeneration in Alzheimer's disease.

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome.

Mimotopes of conformational epitopes in fibrillar beta-amyloid.

Patterned cell culture inside microfluidic devices.

Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.

Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.

A microfluidic culture platform for CNS axonal injury, regeneration and transport.

Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant.

Novel approaches for immunotherapeutic intervention in Alzheimer's disease.

The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways.

Relapsing polychondritis with features of dementia with Lewy bodies.

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.

External force-assisted cell positioning inside microfluidic devices.

Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates.

Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites.

Distinct roles for Mediator Cdk8 module subunits in Drosophila development.

Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.

Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease.

Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization.

Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.

Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.

Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).

A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.

Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.

Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster.

Cross-regulatory protein-protein interactions between Hox and Pax transcription factors.

Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.

Gene expression changes in the course of normal brain aging are sexually dimorphic.

DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype.

Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I.

Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part II.

A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.

Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model.

Abeta DNA vaccination for Alzheimer's disease: focus on disease prevention.

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.

Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.

Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.

Microfluidic Multicompartment Device for Neuroscience Research.

Anti-11[E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: relevance for immunotherapy.

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.

Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.

An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.

Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma.

Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.

Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy.

Frontal Cortex Neuropathology in Dementia Pugilistica.

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.

Delivery of a DNA Vaccine for Alzheimer's Disease by Electroporation versus Gene Gun Generates Potent and Similar Immune Responses.