Xavier Saelens

Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases.

Mitochondrial intermembrane proteins in cell death.

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand.

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death.

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production.

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity.

Toxic proteins released from mitochondria in cell death.

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing.

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.

A novel caspase-2 complex containing TRAF2 and RIP1.

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.

Protein synthesis persists during necrotic cell death.

Necrosis is associated with IL-6 production but apoptosis is not.

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.

Improved design and intranasal delivery of an M2e-based human influenza A vaccine.

Proteome-wide Identification of HtrA2/Omi Substrates.

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis.

CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

An influenza A vaccine based on tetrameric ectodomain of matrix protein 2.

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies.

Pandemic preparedness: toward a universal influenza vaccine.

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments.

Role of IFN-alpha during the acute stage of a swine influenza virus infection.

M2e-based universal influenza A vaccine.

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal.

Controlling influenza by cytotoxic T-cells: calling for help from destroyers.

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective.

Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.

Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection.

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus.

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules.

Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro.

Nanobodies®: new ammunition to battle viruses.

Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion.

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection.

Tailor-made cleavage site attenuates influenza B.

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.

The Sin3a repressor complex is a master regulator of STAT transcriptional activity.

Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.

Influenza vaccines: T-cell responses deserve more attention.

Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.

Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge.

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.

Hepatitis B core-based virus-like particles to present heterologous epitopes.

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A.

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e.

Insight into structural diversity of influenza virus haemagglutinin.

Challenges and advances towards the rational design of mRNA vaccines.

Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system's productivity.

Mx proteins: antiviral gatekeepers that restrain the uninvited.

Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin.

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Influenza vaccines to control influenza-associated bacterial infection: where do we stand?

CD⁸ T cell immunity against human respiratory syncytial virus.

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein.

Sequence-dependent internalization of aggregating peptides.

Structure of the extracellular domain of matrix protein 2 of influenza a virus in complex with a protective monoclonal antibody.

Scop3D: Three-dimensional visualization of sequence conservation.

Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing.

Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen.

A GFP Expressing Influenza A Virus to Report In Vivo Tropism and Protection by a Matrix Protein 2 Ectodomain-Specific Monoclonal Antibody.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages.

Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.

M2e-Based Universal Influenza A Vaccines.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation.

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies.

Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes.

One Against All: A Broadly Influenza Neutralizing Man-made Monoclonal Antibody Passes Phase I.

Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice.

M2-based influenza vaccines: recent advances and clinical potential.

Influenza and Memory T Cells: How to Awake the Force.

Regulation of kynurenine biosynthesis during influenza virus infection.

Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

IgG3 Snitcher of RSV Infections in the Very Young.

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection.

Effect of serial pig passages on the adaptation of an avian H9N2 influenza virus to swine.