Christophe Guilluy

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.

Regulation of Rho proteins by phosphorylation in the cardiovascular system.

Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation.

Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.

Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.

RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.

AMPK alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol.

Latent KSHV infection increases the vascular permeability of human endothelial cells.

Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells.

Rho protein crosstalk: another social network?

The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.

Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus.

From mechanical force to RhoA activation.

Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway.

Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells.

The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration.

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.

Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions.

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells.

Nuclear mechanotransduction: forcing the nucleus to respond.

Focal adhesions, stress fibers and mechanical tension.

Under Pressure: Mechanical Stress Management in the Nucleus.

Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface.