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Herbert Levine

Department of Bioengineering

Rice University

BIOGRAPHY

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PUBLICATIONS

Stability of the hybrid epithelial/mesenchymal phenotype.

Oncotarget Mar, 2016 | Pubmed ID: 27008704

Establishing direction during chemotaxis in eukaryotic cells.

Biophysical journal Sep, 2002 | Pubmed ID: 12202361

Mode-I fracture in a nonlinear lattice with viscoelastic forces.

Physical review. E, Statistical, nonlinear, and soft matter physics Jul, 2002 | Pubmed ID: 12241445

Spectral mixing of rhythmic neuronal signals in sensory cortex.

Proceedings of the National Academy of Sciences of the United States of America Nov, 2002 | Pubmed ID: 12403828

Comment on "dynamics of HIV infection: a cellular automata approach".

Physical review letters Nov, 2002 | Pubmed ID: 12443459

Dynamics of competitive evolution on a smooth landscape.

Physical review letters Feb, 2003 | Pubmed ID: 12633464

Coupled map lattice techniques for simulating interfacial phenomena in reaction-diffusion systems.

Chaos (Woodbury, N.Y.) Jul, 1992 | Pubmed ID: 12779983

Modeling spatial patterns in Dictyostelium.

Chaos (Woodbury, N.Y.) Sep, 1994 | Pubmed ID: 12780133

Wave nucleation rate in excitable systems in the low noise limit.

Physical review. E, Statistical, nonlinear, and soft matter physics Sep, 2003 | Pubmed ID: 14524810

Does the continuum theory of dynamic fracture work?

Physical review. E, Statistical, nonlinear, and soft matter physics Sep, 2003 | Pubmed ID: 14524843

Shunting inhibition controls the gain modulation mediated by asynchronous neurotransmitter release in early development.

PLoS computational biology Nov, 2010 | Pubmed ID: 21079676

Computational approach for modeling intra- and extracellular dynamics.

Physical review. E, Statistical, nonlinear, and soft matter physics Sep, 2003 | Pubmed ID: 14524934

Analytical study of the effect of recombination on evolution via DNA shuffling.

Physical review. E, Statistical, nonlinear, and soft matter physics May, 2004 | Pubmed ID: 15244851

Bacterial linguistic communication and social intelligence.

Trends in microbiology Aug, 2004 | Pubmed ID: 15276612

Domain swapping is a consequence of minimal frustration.

Proceedings of the National Academy of Sciences of the United States of America Sep, 2004 | Pubmed ID: 15361578

Dynamic instabilities of fracture under biaxial strain using a phase field model.

Physical review letters Sep, 2004 | Pubmed ID: 15447417

Recombination dramatically speeds up evolution of finite populations.

Physical review letters Mar, 2005 | Pubmed ID: 15784005

Fluctuation-regularized front propagation dynamics in reaction-diffusion systems.

Physical review letters Apr, 2005 | Pubmed ID: 15904196

Protein oligomerization through domain swapping: role of inter-molecular interactions and protein concentration.

Journal of molecular biology Sep, 2005 | Pubmed ID: 16061250

Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach.

Biophysical journal Nov, 2005 | Pubmed ID: 16126827

Physical schemata underlying biological pattern formation-examples, issues and strategies.

Physical biology Jun, 2004 | Pubmed ID: 16204813

Cooperativity can reduce stochasticity in intracellular calcium dynamics.

Physical biology Jun, 2004 | Pubmed ID: 16204819

Structure of infectious prions: stabilization by domain swapping.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2005 | Pubmed ID: 16260647

Division accuracy in a stochastic model of Min oscillations in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America Jan, 2006 | Pubmed ID: 16387859

Membrane-bound Turing patterns.

Physical review. E, Statistical, nonlinear, and soft matter physics Dec, 2005 | Pubmed ID: 16485979

Front propagation up a reaction rate gradient.

Physical review. E, Statistical, nonlinear, and soft matter physics Dec, 2005 | Pubmed ID: 16486029

Analytic approach to the evolutionary effects of genetic exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics Jan, 2006 | Pubmed ID: 16486222

Directional sensing in eukaryotic chemotaxis: a balanced inactivation model.

Proceedings of the National Academy of Sciences of the United States of America Jun, 2006 | Pubmed ID: 16782813

Embryonic pattern scaling achieved by oppositely directed morphogen gradients.

Physical biology May, 2006 | Pubmed ID: 16829697

Self-engineering capabilities of bacteria.

Journal of the Royal Society, Interface / the Royal Society Feb, 2006 | Pubmed ID: 16849231

Fluctuation-induced instabilities in front propagation up a comoving reaction gradient in two dimensions.

Physical review. E, Statistical, nonlinear, and soft matter physics Jul, 2006 | Pubmed ID: 16907163

Effective stochastic dynamics on a protein folding energy landscape.

The Journal of chemical physics Aug, 2006 | Pubmed ID: 16942260

The astrocyte as a gatekeeper of synaptic information transfer.

Neural computation Feb, 2007 | Pubmed ID: 17206866

Quantifying noise levels of intercellular signals.

Physical review. E, Statistical, nonlinear, and soft matter physics Jun, 2007 | Pubmed ID: 17677298

Folding time predictions from all-atom replica exchange simulations.

Journal of molecular biology Sep, 2007 | Pubmed ID: 17681536

Target-specific and global effectors in gene regulation by MicroRNA.

Biophysical journal Dec, 2007 | Pubmed ID: 17872959

Correlated phenotypic transitions to competence in bacterial colonies.

Physical review. E, Statistical, nonlinear, and soft matter physics Oct, 2007 | Pubmed ID: 17994927

Small regulatory RNAs may sharpen spatial expression patterns.

PLoS computational biology Nov, 2007 | Pubmed ID: 18052540

Astrocytes optimize the synaptic transmission of information.

PLoS computational biology May, 2008 | Pubmed ID: 18516277

Coexistence of amplitude and frequency modulations in intracellular calcium dynamics.

Physical review. E, Statistical, nonlinear, and soft matter physics Mar, 2008 | Pubmed ID: 18517322

Activity-dependent stochastic resonance in recurrent neuronal networks.

Physical review. E, Statistical, nonlinear, and soft matter physics Jun, 2008 | Pubmed ID: 18643209

Receptor noise and directional sensing in eukaryotic chemotaxis.

Physical review letters Jun, 2008 | Pubmed ID: 18643461

Multimodal encoding in a simplified model of intracellular calcium signaling.

Cognitive processing Feb, 2009 | Pubmed ID: 19030904

Receptor noise limitations on chemotactic sensing.

Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19064934

A mathematical analysis of second messenger compartmentalization.

Physical biology Dec, 2008 | Pubmed ID: 19075354

The fixation probability of rare mutators in finite asexual populations.

Genetics Apr, 2009 | Pubmed ID: 19153261

Determining the scale of the Bicoid morphogen gradient.

Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19190186

Mechanisms and constraints on yeast MAPK signaling specificity.

Biophysical journal Jun, 2009 | Pubmed ID: 19527636

Locally balanced dendritic integration by short-term synaptic plasticity and active dendritic conductances.

Journal of neurophysiology Dec, 2009 | Pubmed ID: 19759328

Signal processing in local neuronal circuits based on activity-dependent noise and competition.

Chaos (Woodbury, N.Y.) Sep, 2009 | Pubmed ID: 19791987

Compartmentalization of second messengers in neurons: a mathematical analysis.

Physical review. E, Statistical, nonlinear, and soft matter physics Oct, 2009 | Pubmed ID: 19905336

Phenomenological approach to eukaryotic chemotactic efficiency.

Physical review. E, Statistical, nonlinear, and soft matter physics Mar, 2010 | Pubmed ID: 20365769

External and internal constraints on eukaryotic chemotaxis.

Proceedings of the National Academy of Sciences of the United States of America May, 2010 | Pubmed ID: 20457897

Transient localized patterns in noise-driven reaction-diffusion systems.

Physical review letters Apr, 2010 | Pubmed ID: 20482022

A comparison of deterministic and stochastic simulations of neuronal vesicle release models.

Physical biology May, 2010 | Pubmed ID: 20505227

The role of cell contraction and adhesion in dictyostelium motility.

Biophysical journal Jul, 2010 | Pubmed ID: 20655832

Optimal strategy for competence differentiation in bacteria.

PLoS genetics Sep, 2010 | Pubmed ID: 20838595

Computational model for cell morphodynamics.

Physical review letters Sep, 2010 | Pubmed ID: 20867552

Physical limits on cellular sensing of spatial gradients.

Physical review letters Jul, 2010 | Pubmed ID: 20867888

Gradient sensing in defined chemotactic fields.

Integrative biology : quantitative biosciences from nano to macro Nov, 2010 | Pubmed ID: 20882228

Modelling vesicular release at hippocampal synapses.

PLoS computational biology Nov, 2010 | Pubmed ID: 21085682

Design principles and specificity in biological networks with cross activation.

Physical biology Apr, 2011 | Pubmed ID: 21263168

How geometry and internal bias affect the accuracy of eukaryotic gradient sensing.

Physical review. E, Statistical, nonlinear, and soft matter physics Feb, 2011 | Pubmed ID: 21405873

Quantifying information transmission in eukaryotic gradient sensing and chemotactic response.

Journal of statistical physics Apr, 2011 | Pubmed ID: 21643513

Activated membrane patches guide chemotactic cell motility.

PLoS computational biology Jun, 2011 | Pubmed ID: 21738453

"Self-assisted" amoeboid navigation in complex environments.

PloS one , 2011 | Pubmed ID: 21829602

Propagating mode-I fracture in amorphous materials using the continuous random network model.

Physical review. E, Statistical, nonlinear, and soft matter physics Aug, 2011 | Pubmed ID: 21929059

Effects of input noise on a simple biochemical switch.

Physical review letters Sep, 2011 | Pubmed ID: 22107236

Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway.

Science signaling Jan, 2012 | Pubmed ID: 22215733

Noise effects in nonlinear biochemical signaling.

Physical review. E, Statistical, nonlinear, and soft matter physics Jan, 2012 | Pubmed ID: 22400585

Coupling actin flow, adhesion, and morphology in a computational cell motility model.

Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22493219

Bacterial survival strategies suggest rethinking cancer cooperativity.

Trends in microbiology Sep, 2012 | Pubmed ID: 22750098

Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal.

Proceedings of the National Academy of Sciences of the United States of America Sep, 2012 | Pubmed ID: 22908295

Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing.

Proceedings of the National Academy of Sciences of the United States of America Feb, 2013 | Pubmed ID: 23345440

How input fluctuations reshape the dynamics of a biological switching system.

Physical review. E, Statistical, nonlinear, and soft matter physics Dec, 2012 | Pubmed ID: 23367979

Large population solution of the stochastic Luria-Delbruck evolution model.

Proceedings of the National Academy of Sciences of the United States of America Jul, 2013 | Pubmed ID: 23818583

Energy evaluation of β-strand packing in a fibril-forming SH3 domain.

The journal of physical chemistry. B Oct, 2013 | Pubmed ID: 23819485

We need theoretical physics approaches to study living systems.

Physical biology Aug, 2013 | Pubmed ID: 23883648

Scientific priorities for the BRAIN Initiative.

Nature methods Aug, 2013 | Pubmed ID: 23900253

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination.

Proceedings of the National Academy of Sciences of the United States of America Nov, 2013 | Pubmed ID: 24154725

Periodic migration in a physical model of cells on micropatterns.

Physical review letters Oct, 2013 | Pubmed ID: 24160631

Modeling cell-death patterning during biofilm formation.

Physical biology Dec, 2013 | Pubmed ID: 24275528

Growth feedback as a basis for persister bistability.

Proceedings of the National Academy of Sciences of the United States of America Jan, 2014 | Pubmed ID: 24344277

The physics of eukaryotic chemotaxis.

Physics today Feb, 2013 | Pubmed ID: 24363460

Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information.

Proceedings of the National Academy of Sciences of the United States of America Feb, 2014 | Pubmed ID: 24449878

Physical Biology : challenges for our second decade.

Physical biology Jun, 2014 | Pubmed ID: 24732666

Intercellular stress reconstitution from traction force data.

Biophysical journal Aug, 2014 | Pubmed ID: 25099794

Introduction to physics in cancer research.

Cancer research Sep, 2014 | Pubmed ID: 25183782

Resistance to chemotherapy: patient variability and cellular heterogeneity.

Cancer research Sep, 2014 | Pubmed ID: 25183790

Cellular memory in eukaryotic chemotaxis.

Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25249632

Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns.

Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25258412

Learning physics of living systems from Dictyostelium.

Physical biology Oct, 2014 | Pubmed ID: 25294248

How input noise limits biochemical sensing in ultrasensitive systems.

Physical review. E, Statistical, nonlinear, and soft matter physics Sep, 2014 | Pubmed ID: 25314468

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness.

Journal of the Royal Society, Interface / the Royal Society Dec, 2014 | Pubmed ID: 25339690

Connecting thermal and mechanical protein (un)folding landscapes.

Biophysical journal Dec, 2014 | Pubmed ID: 25517160

Mechanically-driven phase separation in a growing bacterial colony.

Proceedings of the National Academy of Sciences of the United States of America Apr, 2015 | Pubmed ID: 25870260

OVOL guides the epithelial-hybrid-mesenchymal transition.

Oncotarget Jun, 2015 | Pubmed ID: 25944618

Alignment and nonlinear elasticity in biopolymer gels.

Physical review. E, Statistical, nonlinear, and soft matter physics Apr, 2015 | Pubmed ID: 25974530

Properties of cooperatively induced phases in sensing models.

Physical review. E, Statistical, nonlinear, and soft matter physics May, 2015 | Pubmed ID: 26066199

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis.

Frontiers in oncology , 2015 | Pubmed ID: 26258068

Coupling the modules of EMT and stemness: A tunable 'stemness window' model.

Oncotarget Sep, 2015 | Pubmed ID: 26317796

Micromechanics of cellularized biopolymer networks.

Proceedings of the National Academy of Sciences of the United States of America Sep, 2015 | Pubmed ID: 26324923

The motility-proliferation-metabolism interplay during metastatic invasion.

Scientific reports Sep, 2015 | Pubmed ID: 26337223

Nonlinear elasticity of disordered fiber networks.

Soft matter Feb, 2016 | Pubmed ID: 26616428

Excitable waves and direction-sensing in Dictyostelium discoideum: steps towards a chemotaxis model.

Physical biology Jan, 2016 | Pubmed ID: 26824302

Modeling closure of circular wounds through coordinated collective motion.

Physical biology Feb, 2016 | Pubmed ID: 26871883

Scaling solution in the large population limit of the general asymmetric stochastic Luria-Delbrück evolution process.

Journal of statistical physics Feb, 2015 | Pubmed ID: 26900175

Contact inhibition of locomotion determines cell-cell and cell-substrate forces in tissues.

Proceedings of the National Academy of Sciences of the United States of America Mar, 2016 | Pubmed ID: 26903658

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome.

Proceedings of the National Academy of Sciences of the United States of America Mar, 2016 | Pubmed ID: 26929325

Emergent Collective Chemotaxis without Single-Cell Gradient Sensing.

Physical review letters Mar, 2016 | Pubmed ID: 26991203

Tumor Budding: The Name is EMT. Partial EMT.

Journal of clinical medicine Apr, 2016 | Pubmed ID: 27136592

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype.

Journal of the Royal Society, Interface May, 2016 | Pubmed ID: 27170649

Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.

PLoS computational biology Jul, 2016 | Pubmed ID: 27367541

Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.

Molecular and cellular biology Oct, 2016 | Pubmed ID: 27402864

Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins.

Asian journal of andrology Sep-Oct, 2016 | Pubmed ID: 27427552

Expanding the scale of molecular biophysics.

Physical biology Oct, 2016 | Pubmed ID: 27716638

Modeling delayed processes in biological systems.

Physical review. E Sep, 2016 | Pubmed ID: 27739721

Mechanical bounds to transcriptional noise.

Proceedings of the National Academy of Sciences of the United States of America Dec, 2016 | Pubmed ID: 27911801

Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation.

Cancer research Feb, 2017 | Pubmed ID: 28202516

Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.

Physical review. E Jan, 2017 | Pubmed ID: 28208438

The GRHL2/ZEB Feedback Loop - A Key Axis in the Regulation of EMT in Breast Cancer.

Journal of cellular biochemistry Mar, 2017 | Pubmed ID: 28266048

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America Mar, 2017 | Pubmed ID: 28289210

INSTITUTIONS

Rice University

JOVE ARTICLES

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Kathryn E. Ware¹,

Shivee Gilja¹,

Shenghan Xu¹,

Samantha Shetler¹,

Mohit K. Jolly²,

Xueyang Wang³,

Suzanne Bartholf Dewitt⁴,

Alexander J. Hish¹,

Sarah Jordan¹,

William Eward⁵,

Herbert Levine²,

Andrew J. Armstrong⁴,

Jason A. Somarelli¹

¹Department of Medicine, Duke University,

²Department of Bioengineering, Rice University,

³Department of Molecular Genetics and Microbiology, Duke University,

⁴Solid Tumor Program and the Duke Prostate Center, Duke University Medical Center,

⁵, Duke University Medical Center

Developmental Biology

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Herbert Levine

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Bioengineering

Rice University

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Department of Bioengineering