Department of Physiology and Medical Science,
College of Medicine and Brain Research Institute
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Open channel block by KCB-328 [1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride] of the heterologously expressed human ether-a-go-go-related gene K+ channels.
The Journal of pharmacology and experimental therapeutics Jul, 2002 | Pubmed ID: 12065732
Effect of Korea red ginseng on cerebral blood flow and superoxide production.
Acta pharmacologica Sinica Dec, 2002 | Pubmed ID: 12466053
Effect of phosphatidylserine on unitary conductance and Ba2+ block of the BK Ca2+-activated K+ channel: re-examination of the surface charge hypothesis.
The Journal of general physiology May, 2003 | Pubmed ID: 12695485
Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide.
Journal of cardiovascular pharmacology Nov, 2003 | Pubmed ID: 14576514
Molecular and electrophysiological characterization of nucleotide-sensitive chloride current-inducing protein of Fasciola hepatica.
Molecular and biochemical parasitology Apr, 2005 | Pubmed ID: 15760659
Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes.
Acta pharmacologica Sinica May, 2005 | Pubmed ID: 15842772
Characterization of a novel tonic gamma-aminobutyric acidA receptor-mediated inhibition in magnocellular neurosecretory neurons and its modulation by glia.
Endocrinology Aug, 2006 | Pubmed ID: 16675519
Midazolam inhibits proinflammatory mediators in the lipopolysaccharide-activated macrophage.
Anesthesiology Jul, 2006 | Pubmed ID: 16810001
Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes.
Acta pharmacologica Sinica Apr, 2007 | Pubmed ID: 17376289
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
The Journal of physiology Jul, 2007 | Pubmed ID: 17495040
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Lung cancer (Amsterdam, Netherlands) May, 2008 | Pubmed ID: 18061304
Tat-APE1/ref-1 protein inhibits TNF-alpha-induced endothelial cell activation.
Biochemical and biophysical research communications Mar, 2008 | Pubmed ID: 18206643
Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons.
Neuroscience letters Jul, 2008 | Pubmed ID: 18524490
Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats.
FEBS letters Jul, 2008 | Pubmed ID: 18588882
Midazolam inhibits tumor necrosis factor-alpha-induced endothelial activation: involvement of the peripheral benzodiazepine receptor.
Anesthesiology Jan, 2009 | Pubmed ID: 19104177
COMP-Ang1 ameliorates leukocyte adhesion and reinforces endothelial tight junctions during endotoxemia.
Biochemical and biophysical research communications Apr, 2009 | Pubmed ID: 19245790
Endothelial nitric oxide synthase activation contributes to post-exercise hypotension in spontaneously hypertensive rats.
Biochemical and biophysical research communications May, 2009 | Pubmed ID: 19306842
Endogenous expression of TRPV1 channel in cultured human melanocytes.
Journal of dermatological science Nov, 2009 | Pubmed ID: 19656659
Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters.
The Journal of physiology Oct, 2009 | Pubmed ID: 19703969
COMP-Ang1 potentiates the antitumor activity of 5-fluorouracil by improving tissue perfusion in murine Lewis lung carcinoma.
Molecular cancer research : MCR Dec, 2009 | Pubmed ID: 19952114
Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Dec, 2009 | Pubmed ID: 20054488
Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.
American journal of physiology. Regulatory, integrative and comparative physiology Jul, 2010 | Pubmed ID: 20164200
Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis.
FEBS letters Jun, 2010 | Pubmed ID: 20416295
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Jun, 2010 | Pubmed ID: 20631885
Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction.
Neuroscience letters Oct, 2010 | Pubmed ID: 20723582
Tonic extrasynaptic GABA(A) receptor currents control gonadotropin-releasing hormone neuron excitability in the mouse.
Endocrinology Apr, 2011 | Pubmed ID: 21285326
Major role of GABA(A)-receptor mediated tonic inhibition in propofol suppression of supraoptic magnocellular neurons.
Neuroscience letters Apr, 2011 | Pubmed ID: 21376783
Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons.
American journal of physiology. Regulatory, integrative and comparative physiology Jun, 2011 | Pubmed ID: 21451144
Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
Cardiovascular research Aug, 2011 | Pubmed ID: 21467074
Human HOXA5 homeodomain enhances protein transduction and its application to vascular inflammation.
Biochemical and biophysical research communications Jul, 2011 | Pubmed ID: 21664342
Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Jun, 2011 | Pubmed ID: 21860595
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.
Immunology and cell biology Jul, 2012 | Pubmed ID: 21876553
Property of large conductance Ca(2+)-activated K+ channels from Fasciola hepatica incorporated into planar lipid bilayer.
Veterinary parasitology May, 2012 | Pubmed ID: 22154253
Vasorelaxing Activity of Ulmus davidiana Ethanol Extracts in Rats: Activation of Endothelial Nitric Oxide Synthase.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Dec, 2011 | Pubmed ID: 22359471
Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action.
Cell host & microbe May, 2012 | Pubmed ID: 22607799
Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1.
FEBS letters May, 2012 | Pubmed ID: 22616995
Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Jun, 2012 | Pubmed ID: 22802702
Mycobacterium kansasii-induced death of murine macrophages involves endoplasmic reticulum stress responses mediated by reactive oxygen species generation or calpain activation.
Apoptosis : an international journal on programmed cell death Feb, 2013 | Pubmed ID: 23264129
Antinociceptive Effect of Cyperi rhizoma and Corydalis tuber Extracts on Neuropathic Pain in Rats.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Dec, 2012 | Pubmed ID: 23269900
Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice.
Biological & pharmaceutical bulletin , 2013 | Pubmed ID: 23302645
Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats.
Journal of neurophysiology Jul, 2013 | Pubmed ID: 23576696
Arginase II inhibited lipopolysaccharide-induced cell death by regulation of iNOS and Bcl-2 family proteins in macrophages.
Molecules and cells May, 2013 | Pubmed ID: 23639968
Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1.
Biochemical and biophysical research communications Jun, 2013 | Pubmed ID: 23665318
Identification of plasma APE1/Ref-1 in lipopolysaccharide-induced endotoxemic rats: implication of serological biomarker for an endotoxemia.
Biochemical and biophysical research communications Jun, 2013 | Pubmed ID: 23685156
IQGAP1 expression in spared CA1 neurons after an excitotoxic lesion in the mouse hippocampus.
Cellular and molecular neurobiology Oct, 2013 | Pubmed ID: 23907317
Cytoplasmic localization and redox cysteine residue of APE1/Ref-1 are associated with its anti-inflammatory activity in cultured endothelial cells.
Molecules and cells Nov, 2013 | Pubmed ID: 24213673
Mitochondrial APE1/Ref-1 suppressed protein kinase C-induced mitochondrial dysfunction in mouse endothelial cells.
Mitochondrion Jul, 2014 | Pubmed ID: 24861944
Analgesic effect of electroacupuncture on paclitaxel-induced neuropathic pain via spinal opioidergic and adrenergic mechanisms in mice.
The American journal of Chinese medicine , 2015 | Pubmed ID: 25640847
APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.
Cancer research and treatment : official journal of Korean Cancer Association Oct, 2015 | Pubmed ID: 25672588
Adenine suppresses IgE-mediated mast cell activation.
Molecular immunology Jun, 2015 | Pubmed ID: 25700347
Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3.
The Journal of biological chemistry May, 2015 | Pubmed ID: 25829491
Enhanced astroglial GABA uptake attenuates tonic GABAA inhibition of the presympathetic hypothalamic paraventricular nucleus neurons in heart failure.
Journal of neurophysiology Aug, 2015 | Pubmed ID: 26063771
Enhanced astroglial GABA uptake in heart failure.
Channels (Austin, Tex.) , 2015 | Pubmed ID: 26260365
The 18-kDa Translocator Protein Inhibits Vascular Cell Adhesion Molecule-1 Expression via Inhibition of Mitochondrial Reactive Oxygen Species.
Molecules and cells Dec, 2015 | Pubmed ID: 26608360
Altered expression of KCC2 in GABAergic interneuron contributes prenatal stress-induced epileptic spasms in infant rat.
Neurochemistry international Jul, 2016 | Pubmed ID: 27180051
Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Jul, 2016 | Pubmed ID: 27382359
Inoculation of Lewis lung carcinoma cells enhances formalin-induced pain behavior and spinal Fos expression in mice.
Journal of veterinary science Sep, 2017 | Pubmed ID: 27586465
CD200R/Foxp3-mediated signalling regulates microglial activation.
Scientific reports Oct, 2016 | Pubmed ID: 27731341
TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Nov, 2016 | Pubmed ID: 27847442
Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor.
Scientific reports Dec, 2016 | Pubmed ID: 27910870
The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.
Molecular brain Dec, 2016 | Pubmed ID: 27986089
Developmental changes in GABA tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Nov, 2017 | Pubmed ID: 29200913
CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.
PloS one , 2018 | Pubmed ID: 29474366
GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections.
Nature communications 10, 2018 | Pubmed ID: 30305619
C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.
Biochemical pharmacology 12, 2018 | Pubmed ID: 30359578
Exercise training normalizes elevated firing rate of hypothalamic presympathetic neurons in heart failure rats.
American journal of physiology. Regulatory, integrative and comparative physiology 02, 2019 | Pubmed ID: 30485115
The extracellular role of Ref-1 as anti-inflammatory function in lipopolysaccharide-induced septic mice.
Free radical biology & medicine 08, 2019 | Pubmed ID: 31100475
Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats.
Experimental neurobiology Aug, 2019 | Pubmed ID: 31495081
Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi.
Glia 05, 2020 | Pubmed ID: 31833596
Author Correction: CD200R/Foxp3-mediated signalling regulates microglial activation.
Scientific reports Mar, 2020 | Pubmed ID: 32251352
Positive allosteric modulation of GABA receptors by a novel antiepileptic drug cenobamate.
European journal of pharmacology Jul, 2020 | Pubmed ID: 32325146
Alpha-Methylacyl-CoA Racemase (AMACR), a Potential New Biomarker for Glioblastoma.
Frontiers in oncology , 2020 | Pubmed ID: 33154941
High Salt Intake Recruits Tonic Activation of NR2D Subunit-Containing Extrasynaptic NMDARs in Vasopressin Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 02, 2021 | Pubmed ID: 33303677
Bee venom reduces burn-induced pain via the suppression of peripheral and central substance P expression in mice.
Journal of veterinary science Jan, 2021 | Pubmed ID: 33522161
Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice.
Neurochemistry international 06, 2021 | Pubmed ID: 33744374
Electrophysiological Properties of Ion Channels in Ascaris suum Tissue Incorporated into Planar Lipid Bilayers.
The Korean journal of parasitology Aug, 2021 | Pubmed ID: 34470084
Dong-Wook Kang1,
Jae-Gyun Choi1,
Ji-Young Moon2,
Suk-Yun Kang2,
Yeonhee Ryu2,
Jin Bong Park1,
Hyun-Woo Kim1,3
1Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University,
2KM Fundamental Research Division, Korea Institute of Oriental Medicine (KIOM),
3Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston