Division of Molecular Neurogenetics
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Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation.
Neuro-oncology Apr, 2012 | Pubmed ID: 22394497
Role of the nuclear receptor Tailless in adult neural stem cells.
Mechanisms of development Jun-Aug, 2013 | Pubmed ID: 23415832
The chromatin remodeler CHD7 regulates adult neurogenesis via activation of SoxC transcription factors.
Cell stem cell Jul, 2013 | Pubmed ID: 23827709
Epigenetic regulation of neuronal fate determination: the role of CHD7.
Cell cycle (Georgetown, Tex.) Dec, 2013 | Pubmed ID: 24145227
Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival.
Cell stem cell Aug, 2014 | Pubmed ID: 24835569
Revealing the Hidden Powers that Fuel Adult Neurogenesis.
Cell stem cell 02, 2017 | Pubmed ID: 28157496
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
Nature communications Mar, 2017 | Pubmed ID: 28317875
CRISPR-engineered genome editing for the next generation neurological disease modeling.
Progress in neuro-psychopharmacology & biological psychiatry Feb, 2018 | Pubmed ID: 28536069
Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease.
Frontiers in molecular neuroscience , 2017 | Pubmed ID: 29033785
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone.
Genes & development Sep, 2008 | Pubmed ID: 18794344
The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation.
Genes & development Apr, 2010 | Pubmed ID: 20360385
Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.
The American journal of pathology Oct, 2016 | Pubmed ID: 27658714
Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.
Aging cell Jun, 2018 | Pubmed ID: 29504228
Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells.
Blood advances Apr, 2019 | Pubmed ID: 30948364
Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation.
Cell metabolism Aug, 2019 | Pubmed ID: 31056285
GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile.
Cell stem cell Aug, 2019 | Pubmed ID: 31303549
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.
Nature communications Sep, 2019 | Pubmed ID: 31477715
Glutamatergic synaptic input to glioma cells drives brain tumour progression.
Nature 09, 2019 | Pubmed ID: 31534219
A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors.
Cancers Jan, 2021 | Pubmed ID: 33435218
CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum.
Nature communications Sep, 2021 | Pubmed ID: 34588434
Human adult hippocampal neurogenesis is back, again?
Cell research Sep, 2022 | Pubmed ID: 35856092
Artemisinin, GABA signaling and cell reprogramming: when an old drug meets modern medicine.
Science bulletin Mar, 2017 | Pubmed ID: 36659280
CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1.
Cancer cell Oct, 2023 | Pubmed ID: 37683639
A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs.
NPJ precision oncology Jan, 2024 | Pubmed ID: 38273014
SOX10 mediates glioblastoma cell-state plasticity.
EMBO reports Nov, 2024 | Pubmed ID: 39285246
Promotes Stroke-Induced Neurogenesis and Neuronal Repair in Young and Aged Mice.
International journal of molecular sciences Nov, 2024 | Pubmed ID: 39596503
Weijun Feng*,1,
Lena Herbst*,2,
Peter Lichter2,
Stefan M. Pfister3,4,5,
Hai-Kun Liu1,
Daisuke Kawauchi3,4
1Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance,
2Division of Molecular Genetics, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK),
3, Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ),
4Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK),
5Department of Pediatric Hematology and Oncology, Heidelberg University Hospital