Neurogenetics of Vocal Communication
Sonja Vernes investigates how speech and language relevant traits are biologically encoded, how these abilities evolved, and the causes of language related disorders. During her DPhil at the University of Oxford she sought to understand the functions of genes that cause speech and language disorders. She demonstrated how patient mutations in one such gene, FOXP2, cause altered neurodevelopment in mouse and human models, and identified a relationship between FOXP2 and another gene known as CNTNAP2, showing that they represent a novel genetic mechanism shared across clinically distinct language-related syndromes.
In 2016, Dr. Vernes was awarded a Max Planck Research Group (MPRG) Grant and a Human Frontiers Science Program (HFSP) Research Grant to establish a research group at the Max Planck Institute for Psycholinguistics with the goal to use bats for comparative studies of speech and language relevant traits. Her lab, the Neurogenetics of Vocal Communication Group, focuses on the abilities of bats to learn novel vocalisations (vocal learning), a skill that in humans, allows us learn the huge repertoire of sounds we use to communicate via spoken language. Their work has now demonstrated the feasibility of neurogenetic studies in bats, identified sites of action for key language-related genes in the brains of vocal learning bats, and their potential to contribute to our understanding of human speech and language.
To facilitate the use of bats as a neurogenetic model Dr. Vernes, together with Dr. Emma Teeling (UC Dublin), launched the Bat1K genome sequencing consortium (www.bat1k.com). This international research effort is now underway to sequence the genomes of all living bat species to reference quality resolution.
Together, these new research area is allowing us to characterise the genetics and neural circuitry underlying vocal learning in mammals and will ultimately inform our understanding of spoken language in humans.
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.
PLoS genetics Jul, 2011 | Pubmed ID: 21765815
FOXP2 targets show evidence of positive selection in European populations.
American journal of human genetics May, 2013 | Pubmed ID: 23602712
Shining a light on CNTNAP2: complex functions to complex disorders.
European journal of human genetics : EJHG Feb, 2014 | Pubmed ID: 23714751
A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137.
Scientific reports Feb, 2014 | Pubmed ID: 24500708
Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation.
Scientific reports Mar, 2014 | Pubmed ID: 24642956
FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways.
Frontiers in cellular neuroscience , 2014 | Pubmed ID: 25309332
A chromosomal rearrangement in a child with severe speech and language disorder separates FOXP2 from a functional enhancer.
Molecular cytogenetics , 2015 | Pubmed ID: 26300977
A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication.
BMC genomics Oct, 2015 | Pubmed ID: 26490347
Retinoic Acid Signaling: A New Piece in the Spoken Language Puzzle.
Frontiers in psychology , 2015 | Pubmed ID: 26635706
Characterisation of CASPR2 deficiency disorder--a syndrome involving autism, epilepsy and language impairment.
BMC medical genetics Feb, 2016 | Pubmed ID: 26843181
Early developmental gene enhancers affect subcortical volumes in the adult human brain.
Human brain mapping May, 2016 | Pubmed ID: 26890892
What bats have to say about speech and language.
Psychonomic bulletin & review 02, 2017 | Pubmed ID: 27368623
Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level Genomes for All Living Bat Species.
Annual review of animal biosciences 02, 2018 | Pubmed ID: 29166127
Understanding Neurodevelopmental Disorders: The Promise of Regulatory Variation in the 3'UTRome.
Biological psychiatry 04, 2018 | Pubmed ID: 29289333
Mapping the distribution of language related genes FoxP1, FoxP2, and CntnaP2 in the brains of vocal learning bat species.
The Journal of comparative neurology 06, 2018 | Pubmed ID: 29297931
Mapping of Human Enhancers Reveals Complex Regulation.
Frontiers in molecular neuroscience , 2018 | Pubmed ID: 29515369
Taking turns: bridging the gap between human and animal communication.
Proceedings. Biological sciences 06, 2018 | Pubmed ID: 29875303
Volitional control of social vocalisations and vocal usage learning in bats.
The Journal of experimental biology 07, 2018 | Pubmed ID: 29880634
Genome-wide investigation of an ID cohort reveals de novo 3'UTR variants affecting gene expression.
Human genetics Sep, 2018 | Pubmed ID: 30097719
Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release.
Brain structure & function Dec, 2018 | Pubmed ID: 30187194
A Modular Approach to Vocal Learning: Disentangling the Diversity of a Complex Behavioral Trait.
Neuron Oct, 2019 | Pubmed ID: 31600518
Laurel R. Yohe*,1,2,
Paolo Devanna*,3,
Kalina T.J. Davies4,
Joshua H.T. Potter4,
Stephen J. Rossiter4,
Emma C. Teeling5,
Sonja C. Vernes*,3,6,
Liliana M. Dávalos*,2,7
1Department of Geology & Geophysics, Yale University,
2Department of Ecology & Evolution, Stony Brook University,
3Neurogenetics of Vocal Communication, Max Planck Institute for Psycholinguistics,
4School of Biological and Chemical Sciences, Queen Mary University of London,
5School of Biology & Environmental Science, University College Dublin,
6, Donders Institute for Brain, Cognition and Behavior,
7Consortium for Inter-Disciplinary Environmental Research, Stony Brook University