Suzanne Jackowski

Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into glycerolipids in proliferating cells.

Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress.

The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase.

Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.

A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

Forty years of bacterial fatty acid synthesis.

The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes.

Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.

Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform.

PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.

Disruption of CCTbeta2 expression leads to gonadal dysfunction.

Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain.

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a).

Coenzyme A: back in action.

Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.

Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration.

Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.

Role of phosphocholine cytidylyltransferase alpha in lung development.

Phospholipid biosynthesis program underlying membrane expansion during B-lymphocyte differentiation.

Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.

Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice.

Localization and regulation of mouse pantothenate kinase 2.

Cytokine secretion requires phosphatidylcholine synthesis.

Membrane phospholipid synthesis and endoplasmic reticulum function.

CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination.

ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.

Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.

Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.

Phosphatidylcholine biosynthesis during neuronal differentiation and its role in cell fate determination.

Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.

UPR-Mediated Membrane Biogenesis in B Cells.

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.

The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.

Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.

Phosphatidylcholine and the CDP-choline cycle.

Compartmentalization of Mammalian pantothenate kinases.

Preface: phospholipids and phospholipid metabolism.

Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.

Coenzyme A and its derivatives: renaissance of a textbook classic.

Physiological roles of the pantothenate kinases.

Deregulated coenzyme A, loss of metabolic flexibility and diabetes.

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.

Biosynthesis of Pantothenic Acid and Coenzyme A.

Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.

Allosteric Regulation of Mammalian Pantothenate Kinase.

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.

A therapeutic approach to pantothenate kinase associated neurodegeneration.

Human pantothenate kinase 4 is a pseudo-pantothenate kinase.

Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration.

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in .