Kevin Camphausen

Tumor hypoxia: chicken, egg, or a piece of the farm?

Angiogenesis inhibitors and radiotherapy of primary tumours.

Portrait of an editorial board member: Judah Folkman: the father of modern angiogenesis.

Radiation abscopal antitumor effect is mediated through p53.

Development of investigational radiation modifiers.

Optimal scheduling of radiotherapy and angiogenic inhibitors.

Antiangiogenic therapy through copper chelation.

Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy.

Angiogenic tumor markers, antiangiogenic agents and radiation therapy.

Evaluation of copper chelation agents as anti-angiogenic therapy.

Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin: a multitarget approach to radiosensitization.

Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.

Clinical trial of endorectal amifostine for radioprotection in patients with prostate cancer: rationale and early results.

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

In vivo tumor imaging using a near-infrared-labeled endostatin molecule.

Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy.

Isoprostane levels in the urine of patients with prostate cancer receiving radiotherapy are not elevated.

Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.

In vivo tumor imaging in mice with near-infrared labeled endostatin.

Combining radiation and molecular targeting in cancer therapy.

Microarray analysis in clinical oncology: pre-clinical optimization using needle core biopsies from xenograft tumors.

External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing.

Transcriptional signature of flavopiridol-induced tumor cell death.

MRI-guided HDR prostate brachytherapy in standard 1.5T scanner.

Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis.

System for prostate brachytherapy and biopsy in a standard 1.5 T MRI scanner.

Evaluation of chelating agents as anti-angiogenic therapy through copper chelation.

Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation.

Optical imaging of mice in oncologic research.

Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.

Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid.

Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.

Inverse treatment planning based on MRI for HDR prostate brachytherapy.

Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer.

Influence of in vivo growth on human glioma cell line gene expression: convergent profiles under orthotopic conditions.

Early ipsilateral breast tumor recurrences after breast conservation affect survival: an analysis of the National Cancer Institute randomized trial.

The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumors.

Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine.

An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement.

Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma.

A novel 3D volumetric voxel registration technique for volume-view-guided image registration of multiple imaging modalities.

Implications for tumor control during protection of normal tissues with antioxidants.

Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy.

ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition.

Orthotopic growth of human glioma cells quantitatively and qualitatively influences radiation-induced changes in gene expression.

Combining radiotherapy and angiogenesis inhibitors: clinical trial design.

Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer.

Transrectal prostate biopsy and fiducial marker placement in a standard 1.5T magnetic resonance imaging scanner.

Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes.

Discovering clinical biomarkers of ionizing radiation exposure with serum proteomic analysis.

A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma.

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.

In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone).

Why "radiation oncology".

Intra- and inter-radiation therapist reproducibility of daily isocenter verification using prostatic fiducial markers.

Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study.

Histone deacetylation as a target for radiosensitization.

A pilot trial of a carcinoembryonic antigen/ TRICOM-based vaccine and radiation to liver metastases in patients with carcinoembryonic antigen-positive solid tumors.

Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells.

Clinical relevance of maspin expression in bladder cancer.

Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided high dose rate brachytherapy boost.

Tumor-directed radiation and the immunotoxin SS1P in the treatment of mesothelin-expressing tumor xenografts.

An endogenous inhibitor of angiogenesis derived from a transitional cell carcinoma: clipped beta2-glycoprotein-I.

Inhibition of hsp90 compromises the DNA damage response to radiation.

Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.

The needle in the haystack: application of breast fine-needle aspirate samples to quantitative protein microarray technology.

Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study.

Synergistic antitumor activity of immune strategies combined with radiation.

Inhibition of Hsp90: a multitarget approach to radiosensitization.

Inhibition of histone deacetylation: a strategy for tumor radiosensitization.

Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score.

Advancement of antiangiogenic and vascular disrupting agents combined with radiation.

In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide.

Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects.

Post-collection, pre-measurement variables affecting VEGF levels in urine biospecimens.

Clinical biomarkers of angiogenesis inhibition.

Radiation-induced gene translation profiles reveal tumor type and cancer-specific components.

The use of chelated radionuclide (samarium-153-ethylenediaminetetramethylenephosphonate) to modulate phenotype of tumor cells and enhance T cell-mediated killing.

Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant.

Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations.

Postradiation sensitization of the histone deacetylase inhibitor valproic acid.

Neuropsychological testing and biomarkers in the management of brain metastases.

Topology of the heterogeneous nature of the extracellular matrix on stochastic modeling of tumor-induced angiogenesis.

Accuracy of 3D volumetric image registration based on CT, MR and PET/CT phantom experiments.

Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma.

In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.

Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate.

Nanoscintillator conjugates as photodynamic therapy-based radiosensitizers: calculation of required physical parameters.

Molecular targets for tumor radiosensitization.

In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase.

Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.

Seminars in Radiation Oncology. Introduction.

Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis.

Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts.

A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change.

Urine analysis and protein networking identify met as a marker of metastatic prostate cancer.

Outcomes of malignant CNS ependymomas: an examination of 2408 cases through the Surveillance, Epidemiology, and End Results (SEER) database (1973-2005).

CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines.

High throughput evaluation of gamma-H2AX.

Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.

Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination?

A dosimetric comparison of four treatment planning methods for high grade glioma.

Gene expression pathway analysis to predict response to neoadjuvant docetaxel and capecitabine for breast cancer.

Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas.

Prospective evaluation of radiosurgery for hemangioblastomas in von Hippel-Lindau disease.

HDAC inhibitors in cancer care.

Cancer stem cells as a prognostic indicator for glioblastoma multiforme.

Biomarkers in radiation oncology.

Research highlights.

Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102.

Parameters favorable to intraprostatic radiation dose escalation in men with localized prostate cancer.

Microenvironmental regulation of glioblastoma radioresponse.

Noninvasive imaging of cell death using an Hsp90 ligand.

Correction of motion-induced misalignment in co-registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery.

Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic.

A pilot feasibility study of TNFeradeâ„¢ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer.

Brain metastases as preventive and therapeutic targets.

Surgical management of melanoma brain metastases in patients treated with immunotherapy.

Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma.

Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept.

A phase 1b trial of the combination of the antiangiogenic agent sunitinib and radiation therapy for patients with primary and metastatic central nervous system malignancies.

Enhancement of 5-fluorouracil-induced in vitro and in vivo radiosensitization with MEK inhibition.

Infratentorial craniospinal irradiation for von Hippel-Lindau: a retrospective study supporting a new treatment for patients with CNS hemangioblastomas.

Research highlights.

A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver.

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.

An MRI-compatible robotic system with hybrid tracking for MRI-guided prostate intervention.

A phase 2 study of pegylated interferon α-2b (PEG-Intron®) in children with diffuse intrinsic pontine glioma.

EGFR isoforms in exosomes as a novel method for biomarker discovery in pancreatic cancer.

Twenty-five year results of the national cancer institute randomized breast conservation trial.

Exosome characterization from ascitic fluid holds promise for identifying markers of colorectal cancer.

Analysis of urinary exosomes to identify new markers of non-small-cell lung cancer.

Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage.

Role of Early Postradiation Magnetic Resonance Imaging Scans in Children with Diffuse Intrinsic Pontine Glioma.

Post-radiation increase in VEGF enhances glioma cell motility in vitro.

Radiosensitization by the novel DNA intercalating agent vosaroxin.