VCU Lipidomics/Metabolomics Shared Resource
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Sphingolipidomics: methods for the comprehensive analysis of sphingolipids.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Sep, 2009 | Pubmed ID: 19147416
Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels.
Journal of lipid research Mar, 2010 | Pubmed ID: 19654423
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Cancer research Sep, 2009 | Pubmed ID: 19723667
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Science (New York, N.Y.) Sep, 2009 | Pubmed ID: 19729656
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.
The Journal of biological chemistry Apr, 2010 | Pubmed ID: 20110355
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Nature Jun, 2010 | Pubmed ID: 20577214
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2011 | Pubmed ID: 20959514
Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry.
Journal of lipid research Aug, 2011 | Pubmed ID: 21586681
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22052905
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Cancer research Feb, 2012 | Pubmed ID: 22298596
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
The Journal of allergy and clinical immunology Feb, 2013 | Pubmed ID: 22939756
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2013 | Pubmed ID: 23180825
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Cancer cell Jan, 2013 | Pubmed ID: 23273921
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.
Disease models & mechanisms Jan, 2014 | Pubmed ID: 24077965
Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.
The Journal of biological chemistry Jan, 2014 | Pubmed ID: 24318881
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Nature immunology Mar, 2014 | Pubmed ID: 24464131
Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.
PloS one , 2014 | Pubmed ID: 24714781
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
Nature neuroscience Jul, 2014 | Pubmed ID: 24859201
Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2014 | Pubmed ID: 25002116
Description of the sphingolipid content and subspecies in the diabetic cornea.
Current eye research , 2015 | Pubmed ID: 25426847
Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.
The Journal of biological chemistry Mar, 2015 | Pubmed ID: 25627684
Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.
The Journal of allergy and clinical immunology Oct, 2015 | Pubmed ID: 25842287
Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration.
Journal of lipid research 05, 2016 | Pubmed ID: 26947037
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.
Journal of mammary gland biology and neoplasia 06, 2016 | Pubmed ID: 27194029
ORMDL proteins regulate ceramide levels during sterile inflammation.
Journal of lipid research 08, 2016 | Pubmed ID: 27313060
Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods.
Heliyon Dec, 2016 | Pubmed ID: 28054036
Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients.
Journal of lipid research Apr, 2017 | Pubmed ID: 28188148
The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans.
Biochimica et biophysica acta Dec, 2017 | Pubmed ID: 29291962
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
Cancer research Apr, 2018 | Pubmed ID: 29351902
Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition.
The ocular surface 04, 2019 | Pubmed ID: 30553001
Analysis of sphingolipid composition in human vitreous from control and diabetic individuals.
Journal of diabetes and its complications 03, 2019 | Pubmed ID: 30630661
Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma.
Leukemia 12, 2019 | Pubmed ID: 31097785
Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage.
Scientific reports 05, 2019 | Pubmed ID: 31123291
Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination.
Journal of lipid research 04, 2020 | Pubmed ID: 32041816
A simple method for sphingolipid analysis of tissues embedded in optimal cutting temperature compound.
Journal of lipid research 06, 2020 | Pubmed ID: 32341007