Glen F. Tibbits

Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping.

Ontogeny of excitation-contraction coupling in the mammalian heart.

Beating the cold: the functional evolution of troponin C in teleost fish.

Determinants of cardiac Na(+)/Ca(2+) exchanger temperature dependence: NH(2)-terminal transmembrane segments.

Temperature dependence of cardiac Na+/Ca2+ exchanger.

Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II.

Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C.

Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes.

Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes.

Phylogeny of Na+/Ca2+ exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species.

cDNA cloning and expression of the cardiac Na+/Ca2+ exchanger from Mozambique tilapia (Oreochromis mossambicus) reveal a teleost membrane transporter with mammalian temperature dependence.

L-type Ca2+ channel function and expression in neonatal rabbit ventricular myocytes.

Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.

SR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes.

Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.

Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery.

Ontogeny of Ca2+-induced Ca2+ release in rabbit ventricular myocytes.

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.

Gene structure evolution of the Na+-Ca2+ exchanger (NCX) family.

Characterization of zebrafish (Danio rerio) NCX4: a novel NCX with distinct electrophysiological properties.

Distribution patterns of the Na+-Ca2+ exchanger and caveolin-3 in developing rabbit cardiomyocytes.

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs.

Calcium handling in zebrafish ventricular myocytes.

Colocalization of voltage-gated Na+ channels with the Na+/Ca2+ exchanger in rabbit cardiomyocytes during development.

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation.

The structure of cardiac troponin C regulatory domain with bound Cd2+ reveals a closed conformation and unique ion coordination.

Adult teleost heart expresses two distinct troponin C paralogs: cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner.

Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*.

Phenotype-dependent role of the L-type calcium current in embryonic stem cell derived cardiomyocytes.

Optical mapping of the electrical activity of isolated adult zebrafish hearts: acute effects of temperature.

Morphological phenotyping of mouse hearts using optical coherence tomography.

Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation.

Functional Assessment of Cardiac Responses of Adult Zebrafish (Danio rerio) to Acute and Chronic Temperature Change Using High-Resolution Echocardiography.

Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC.

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC.

Ischemia-reperfusion destabilizes rhythmicity in immature atrioventricular pacemakers: A predisposing factor for postoperative arrhythmias in neonate rabbits.

The Zebrafish Heart as a Model of Mammalian Cardiac Function.

Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome.

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca-sensitizing mutations.

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue.

Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis.

pH recovery from a proton load in rat cardiomyocytes: effects of chronic exercise.

Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis.

Zebrafish as a model of mammalian cardiac function: Optically mapping the interplay of temperature and rate on voltage and calcium dynamics.

ROCK2 promotes ryanodine receptor phosphorylation and arrhythmic calcium release in diabetic cardiomyocytes.

In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm.

In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants.

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes.

Physiological phenotyping of the adult zebrafish heart.

Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.

The hERG channel activator, RPR260243, enhances protective current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.

Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes.

Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.

Binding of calcium and magnesium to human cardiac troponin C.

Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling.

Investigating inherited arrhythmias using hiPSC-derived cardiomyocytes.

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243.

Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: A Translational Perspective for the Clinician-Scientist.

Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia.

Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T () Variant I79N.

RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes.

The effect of Mg on Ca binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants.

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation.