Thijn R. Brummelkamp

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.

A generic strategy for CRISPR-Cas9-mediated gene tagging.

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

A system for stable expression of short interfering RNAs in mammalian cells.

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

Stable suppression of tumorigenicity by virus-mediated RNA interference.

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

New tools for functional mammalian cancer genetics.

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition.

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Functional annotation of deubiquitinating enzymes using RNA interference.

A genomic and functional inventory of deubiquitinating enzymes.

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

shRNA libraries and their use in cancer genetics.

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

Ebola virus entry requires the host-programmed recognition of an intracellular receptor.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

A reversible gene trap collection empowers haploid genetics in human cells.

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

Emerging intracellular receptors for hemorrhagic fever viruses.

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

GENE REGULATION. A HUSH for transgene expression.

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Gene essentiality and synthetic lethality in haploid human cells.

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

Enterovirus D68 receptor requirements unveiled by haploid genetics.

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

Vasohibins encode tubulin detyrosinating activity.

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

Viral escape from endosomes and host detection at a glance.

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

The Tubulin Detyrosination Cycle: Function and Enzymes.

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

LZTR1 is a regulator of RAS ubiquitination and signaling.

Protocadherin-1 is essential for cell entry by New World hantaviruses.

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.

regulates the action of nitrogen-containing bisphosphonates on bone.

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.

A Mediator-cohesin axis controls heterochromatin domain formation.

Posttranslational modification of microtubules by the MATCAP detyrosinase.

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.

Actin maturation requires the ACTMAP/C19orf54 protease.