Oncode Institute and Division of Biochemistry
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Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.
eLife , 2015 | Pubmed ID: 26698106
A generic strategy for CRISPR-Cas9-mediated gene tagging.
Nature communications Dec, 2015 | Pubmed ID: 26674669
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Chemistry & biology Dec, 2015 | Pubmed ID: 26687144
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.
The Journal of biological chemistry Feb, 2002 | Pubmed ID: 11748239
A system for stable expression of short interfering RNAs in mammalian cells.
Science (New York, N.Y.) Apr, 2002 | Pubmed ID: 11910072
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.
Genes & development Mar, 2002 | Pubmed ID: 11914273
Stable suppression of tumorigenicity by virus-mediated RNA interference.
Cancer cell Sep, 2002 | Pubmed ID: 12242156
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
EMBO reports Jun, 2003 | Pubmed ID: 12776180
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
Nature Aug, 2003 | Pubmed ID: 12917690
New tools for functional mammalian cancer genetics.
Nature reviews. Cancer Oct, 2003 | Pubmed ID: 14570045
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition.
Journal of virology Mar, 2004 | Pubmed ID: 14963165
A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Nature Mar, 2004 | Pubmed ID: 15042092
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Molecular cell Feb, 2005 | Pubmed ID: 15694335
Functional annotation of deubiquitinating enzymes using RNA interference.
Methods in enzymology , 2005 | Pubmed ID: 16275358
A genomic and functional inventory of deubiquitinating enzymes.
Cell Dec, 2005 | Pubmed ID: 16325574
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.
Nature chemical biology Apr, 2006 | Pubmed ID: 16474381
shRNA libraries and their use in cancer genetics.
Nature methods Sep, 2006 | Pubmed ID: 16929315
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.
Molecular cancer research : MCR Sep, 2008 | Pubmed ID: 18723828
Ebola virus entry requires the host-programmed recognition of an intracellular receptor.
The EMBO journal Apr, 2012 | Pubmed ID: 22395071
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23297415
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.
Science (New York, N.Y.) Apr, 2013 | Pubmed ID: 23519211
A reversible gene trap collection empowers haploid genetics in human cells.
Nature methods Oct, 2013 | Pubmed ID: 24161985
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.
Cell reports Apr, 2014 | Pubmed ID: 24685140
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2014 | Pubmed ID: 24737893
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.
Science (New York, N.Y.) Jun, 2014 | Pubmed ID: 24904167
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Science (New York, N.Y.) Jun, 2014 | Pubmed ID: 24970085
USP9X downregulation renders breast cancer cells resistant to tamoxifen.
Cancer research Jul, 2014 | Pubmed ID: 25028367
GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 25031321
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.
Nature chemical biology Sep, 2014 | Pubmed ID: 25064833
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.
Genome research Dec, 2014 | Pubmed ID: 25373145
Emerging intracellular receptors for hemorrhagic fever viruses.
Trends in microbiology Jul, 2015 | Pubmed ID: 26004032
Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.
mBio May, 2015 | Pubmed ID: 26015498
GENE REGULATION. A HUSH for transgene expression.
Science (New York, N.Y.) Jun, 2015 | Pubmed ID: 26113708
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.
mBio Jun, 2015 | Pubmed ID: 26126854
Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.
Cancer research Oct, 2015 | Pubmed ID: 26260527
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.
eLife Sep, 2015 | Pubmed ID: 26327695
Gene essentiality and synthetic lethality in haploid human cells.
Science (New York, N.Y.) Nov, 2015 | Pubmed ID: 26472760
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
The EMBO journal Dec, 2015 | Pubmed ID: 26530471
A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.
Journal of virology Feb, 2016 | Pubmed ID: 26581979
Enterovirus D68 receptor requirements unveiled by haploid genetics.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26787879
A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.
mSphere , 2016 | Pubmed ID: 27303731
PLA2G16 represents a switch between entry and clearance of Picornaviridae.
Nature , | Pubmed ID: 28077878
The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.
Cell May, 2017 | Pubmed ID: 28475897
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.
Nature Jun, 2017 | Pubmed ID: 28562590
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Nature Sep, 2017 | Pubmed ID: 28813410
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.
Cell host & microbe Oct, 2017 | Pubmed ID: 29024641
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.
Cell host & microbe Nov, 2017 | Pubmed ID: 29120745
Vasohibins encode tubulin detyrosinating activity.
Science (New York, N.Y.) , | Pubmed ID: 29146869
BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.
Cell reports Feb, 2018 | Pubmed ID: 29425499
KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.
Cell host & microbe May, 2018 | Pubmed ID: 29681460
Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.
Molecular oncology Jun, 2018 | Pubmed ID: 29689640
Viral escape from endosomes and host detection at a glance.
Journal of cell science Aug, 2018 | Pubmed ID: 30076240
Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.
Current biology : CB Sep, 2018 | Pubmed ID: 30122526
The Tubulin Detyrosination Cycle: Function and Enzymes.
Trends in cell biology Jan, 2019 | Pubmed ID: 30213517
Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.
Cancer research Dec, 2018 | Pubmed ID: 30213788
LZTR1 is a regulator of RAS ubiquitination and signaling.
Science (New York, N.Y.) Dec, 2018 | Pubmed ID: 30442766
Protocadherin-1 is essential for cell entry by New World hantaviruses.
Nature 11, 2018 | Pubmed ID: 30464266
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.
Nature communications Jan, 2019 | Pubmed ID: 30626869
SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.
PloS one , 2019 | Pubmed ID: 30753225
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
Nature medicine Apr, 2019 | Pubmed ID: 30833751
A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.
Journal of virology Jul, 2019 | Pubmed ID: 30996093
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.
Nature structural & molecular biology , | Pubmed ID: 31270470
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Nature communications Feb, 2020 | Pubmed ID: 32111832
regulates the action of nitrogen-containing bisphosphonates on bone.
Science translational medicine May, 2020 | Pubmed ID: 32434850
Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.
Science signaling Sep, 2020 | Pubmed ID: 32934076
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.
Immunity Jan, 2021 | Pubmed ID: 33271119
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2021 | Pubmed ID: 33443154
A Mediator-cohesin axis controls heterochromatin domain formation.
Nature communications Feb, 2022 | Pubmed ID: 35136067
Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science (New York, N.Y.) May, 2022 | Pubmed ID: 35482892
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.
Nature structural & molecular biology Jun, 2022 | Pubmed ID: 35710836
Actin maturation requires the ACTMAP/C19orf54 protease.
Science (New York, N.Y.) Sep, 2022 | Pubmed ID: 36173861
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