Mariko Kobayashi

Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.

Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice.

A network system of medical and welfare information service for the patients, their families, hospitals, local governments, and commercial companies in a medical service area.

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice.

Randomized, controlled trial of natural interferon-alpha therapy for e-antigen-positive chronic hepatitis B patients.

Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in Japan.

The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.

Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.

Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load.

Serum levels of gamma-globulin and total bilirubin influence the prevalence of multiple extrahepatic complication in patients with hepatitis C virus infection.

Phosphorylation state of tau in the hippocampus of apolipoprotein E4 and E3 knock-in mice.

Randomized trial of prolonged interferon retreatment for chronic hepatitis C patients with HCV-genotype 1b and high virus load.

HBe antigen loss during lamivudine therapy is not caused by mutations in precore and core promoter genes in patients with chronic hepatitis B.

Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.

Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan.

Clinical features of hepatitis B virus genotype A in Japanese patients.

Virological and biochemical relapse according to YMDD motif mutant type during long-term lamivudine monotherapy.

Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus.

A pilot study of thymosin alpha1 therapy for chronic hepatitis B patients.

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.

Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.

Sustained negativity for HCV-RNA over 24 or more months by long-term interferon therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load.

Effect of acute self-limited hepatitis C virus (HCV) superinfection on hepatitis B virus (HBV)-related cirrhosis. Virological features of HBV-HCV dual infection.

Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy.

Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.

Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain.

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection.

Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis.

YMDD mutants in patients with chronic hepatitis B before treatment are not selected by lamivudine.

Single-stage repair of complete atrioventricular septal defect and coarctation of the aorta in neonate.

Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.

Interferon therapy for 2 years or longer reduces the incidence of hepatocarcinogenesis in patients with chronic hepatitis C viral infection.

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.

Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis.

Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.

Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up.

Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study.

Hepatocyte steatosis is an important predictor of response to interferon (IFN) monotherapy in Japanese patients infected with HCV genotype 2a: Virological features of IFN-resistant cases with hepatocyte steatosis.

Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan.

Bioprosthetic dysfunction caused by preserved native valve in tricuspid position.

Significance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C.

Virological and biochemical relapse after discontinuation of lamivudine monotherapy for chronic hepatitis B in Japan: comparison with breakthrough hepatitis during long-term treatment.

Virological differences between patients infected with subtypes Ba and Bj of hepatitis B virus genotype B.

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy.

Usefulness of the serum KL-6 assay in patients with hepatitis C virus.

Long-term follow-up of interferon monotherapy in 454 consecutive naive patients infected with hepatitis C virus: multi-course interferon therapy may reduce the risk of hepatocellular carcinoma and increase survival.

Cysteamine or beta-mercaptoethanol added to a defined maturation medium improves blastocyst formation of porcine oocytes after intracytoplasmic sperm injection.

Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.

Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C.

Ross procedure in an infant weighing 4.5 kg: eight years follow-up.

Retentive force of O-ring attachment to use Immediate Provisional Implant (IPI)-retained overdenture.

Clinical and virological features of non-breakthrough and severe exacerbation due to lamivudine-resistant hepatitis B virus mutants.

Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance.

Efficacy of interferon therapy in elderly patients with chronic hepatitis C.

Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.

Functional analysis of hepatitis C virus envelope proteins, using a cell-cell fusion assay.

Arterial switch operation using aortic homograft for transposition of the great arteries with pulmonary regurgitation.

Developmental capacity of Antarctic minke whale ( Balaenoptera bonaerensis ) vitrified oocytes following in vitro maturation, and parthenogenetic activation or intracytoplasmic sperm injection.

In vitro culture conditions using chemically defined media for in vitro matured and intracytoplasmically inseminated porcine oocytes.

Response to long-term lamivudine treatment in patients infected with hepatitis B virus genotypes A, B, and C.

Classification of hepatitis B virus genotypes by the PCR-Invader method with genotype-specific probes.

Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population.

Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: amino acid substitutions in the core region and low-density lipoprotein cholesterol levels.

Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C.

Versatile roles of R-Ras GAP in neurite formation of PC12 cells and embryonic vascular development.

A nucleotide sequence variation detection system for the core region of hepatitis C virus-1b.

Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance.

Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H.

Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains.

Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons.

Changes in viral loads of lamivudine-resistant mutants during entecavir therapy.

Low serum level of hepatitis B core-related antigen indicates unlikely reactivation of hepatitis after cessation of lamivudine therapy.

Prolonged-interferon therapy reduces hepatocarcinogenesis in aged-patients with chronic hepatitis C.

Comparison of interferon and lamivudine treatment in Japanese patients with HBeAg positive chronic hepatitis B.

Amino acid substitutions in the hepatitis C virus core region are the important predictor of hepatocarcinogenesis.

Ideal timing of surgical repair of isolated complete atrioventricular septal defect.

Serum KL-6 level is elevated in chronic hepatitis C patients with combination therapy of pegylated interferon and ribavirin.

Loss of hepatitis B surface antigen from the serum of patients with chronic hepatitis treated with lamivudine.

Interferon-induced prolonged biochemical response reduces hepatocarcinogenesis in hepatitis C virus infection.

Prediction of response to pegylated interferon and ribavirin in hepatitis C by polymorphisms in the viral core protein and very early dynamics of viremia.

Predictors of viral kinetics to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b.

Side effects of combination therapy of peginterferon and ribavirin for chronic hepatitis-C.

Prolonged hepatitis after acute infection with genotype H hepatitis B virus.

[Psychiatric background of social withdrawal in adolescence].

Efficacy in patients with dose reduction in combination therapy of peginterferon and ribavirin for chronic hepatitis C.

The efficacy of short-term interferon-beta therapy for chronic hepatitis C patients with low virus load.

Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.

The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan.

Substitution of amino acid 70 in the hepatitis C virus core region of genotype 1b is an important predictor of elevated alpha-fetoprotein in patients without hepatocellular carcinoma.

Efficacy of low-dose intermittent interferon-alpha monotherapy in patients infected with hepatitis C virus genotype 1b who were predicted or failed to respond to pegylated interferon plus ribavirin combination therapy.

The efficacy of short-term interferon-beta therapy for type C cirrhotic patients with genotype 2a and low virus load.

Suitable treatment period in patients with virological response during combination therapy of peginterferon and ribavirin for chronic hepatitis C.

Binocular open-view Shack-Hartmann wavefront sensor with consecutive measurements of near triad and spherical aberration.

Change of hepatitis B virus genotypes in acute and chronic infections in Japan.

The efficacy of 24-week interferon monotherapy for type C liver cirrhosis in Japanese patients with genotype 1b and low virus load.

Natural human interferon beta plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus and a high viral load.

Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients.

Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene.

A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation.

Outcomes following surgical repair of aortic arch obstructions with associated cardiac anomalies.

A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan: amino acid substitutions in HCV core region as predictor of sustained virological response.

Effect of implant support on distal-extension removable partial dentures: in vivo assessment.

Efficacy of entecavir treatment for lamivudine-resistant hepatitis B over 3 years: histological improvement or entecavir resistance?

Virological response and hepatocarcinogenesis in lamivudine-resistant hepatitis B virus genotype C patients treated with lamivudine plus adefovir dipivoxil.

Combination therapy of peginterferon and ribavirin for chronic hepatitis C patients with genotype 1b and low-virus load.

Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells.

Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus.

Development of hepatocellular carcinoma in elderly patients with chronic hepatitis C with or without elevated aspartate and alanine aminotransferase levels.

Virological and biochemical features in elderly HCV patients with hepatocellular carcinoma: amino acid substitutions in HCV core region as predictor of mortality after first treatment.

Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), pegylated interferon and ribavirin for 12 weeks.

Losartan reduces the onset of type 2 diabetes in hypertensive Japanese patients with chronic hepatitis C.

The efficacy of interferon-beta monotherapy for elderly patients with type C hepatitis of genotype 2.

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy.

Development of a disposable maglev centrifugal blood pump intended for one-month support in bridge-to-bridge applications: in vitro and initial in vivo evaluation.

Glucose depletion enhances sensitivity to shear stress-induced mechanical damage in red blood cells by rotary blood pumps.

Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment.

Sustained virological response in a patient with chronic hepatitis C treated by monotherapy with the NS3-4A protease inhibitor telaprevir.

N-Hexyl-4-aminobutyl glycosides for investigating structures and biological functions of carbohydrates.

Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b.

Association of HLA-DR14 with the treatment response in Japanese patients with autoimmune hepatitis.

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.

Implant overdenture using Konus telescope on one-piece implant: a case report.

长期 (5 年以上） 拉米夫定治疗的病毒学及临床疗效。

Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin.

Extending combination therapy with peginterferon plus ribavirin for genotype 2 chronic hepatitis C virological responders: a pilot study of 7 cases.

Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.

Early in vivo evaluation of ventricular assistance with a miniature centrifugal blood pump (TinyPump) in rabbits.

[Cost-effectiveness analysis of chemotherapy with GEM or S-1 for patients with non-resectable pancreatic cancer].

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 1b and high virus load.

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 2 and high virus load.

Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients.

Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.

HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy.

Rapid detection of drug-resistant mutations in hepatitis B virus by the PCR-Invader assay.

Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons.

Performance of extracorporeally adjustable ventricular assist device inflow cannula.

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells.

HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.

Accuracy of oral mucosal thickness measurements using spiral computed tomography.

Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir.

Amino Acid Substitution in HCV Core Region and Genetic Variation near the IL28B Gene Affect Viral Dynamics during Telaprevir, Peginterferon and Ribavirin Treatment.

Efficacy and safety in sitagliptin therapy for diabetes complicated by chronic liver disease caused by hepatitis C virus.

Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy.

Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.

The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease.

In vivo evaluation of the "TinyPump" as a pediatric left ventricular assist device.

IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C.

Long-term clinical evaluation of implant over denture.

Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy.

In vivo evaluation of a new surfactant polymer coating mimicking the glycocalyx of endothelial cells.

Development rate of chronic kidney disease in hepatitis C virus patients with advanced fibrosis after interferon therapy.

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients.

Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B.

Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients.

Prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhosis with fasting plasma glucose level of <126 mg/dL.

Long-term efficacy of interferon therapy in patients with chronic hepatitis B virus infection in Japan.

Determinants of the clinical outcome of patients with severe acute exacerbation of chronic hepatitis B virus infection.

Functional mitral regurgitation: modern concepts for ventricular geometry reshaping.

Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus.

Hemodynamic differences between the awake and anesthetized conditions in normal calves.