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A Single-Channel and Non-Invasive Wearable Brain-Computer Interface for Industry and Healthcare

The present work focuses on how to build a wearable brain-computer interface (BCI). BCIs are a novel means of human-computer interaction that relies on ...

University of Naples Federico II

The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner. FeHA applied a higher contrast enhancement, and had a longer endurance in the liver with respect to Endorem® at iron equality. Additionally, a proof of concept of FeHA use as scintigraphy imaging agent for positron emission tomography (PET) and single photon emission computed tomography (SPECT) was given labeling FeHA with Tc-MDP by a straightforward surface functionalization process. Scintigraphy/x-ray fused imaging and ex vivo studies confirmed its dominant accumulation in the liver, and secondarily in other organs of the mononuclear phagocyte system. FeHA efficiency as MRI-T and PET-SPECT imaging agent combined to its already reported intrinsic biocompatibility qualifies it as a promising material for innovative nanomedical applications.

On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging.

A method for monitoring the misalignment of the magnetic axis in solenoids is proposed. This method requires only a few measurements of the magnetic field at fixed positions inside the magnet aperture, and thus overcomes the main drawback of sturdy moving mechanics of other Hall sensor-based methods. Conversely to state-of-the-art axis determination, the proposed method can be applied also during magnet operations, when the axis region and almost the whole remaining magnet aperture are not accessible. Moreover, only a few measurements of the magnetic field at fixed positions inside the magnet aperture are required: thus a slow process such as the mapping of the whole aperture of a magnet by means of moving stages is not necessary. The mathematical formulation of the method is explained, and a case study on a model of a multi-layer solenoid is presented. For this case study, the uncertainty is assessed and the optimal placement of the Hall transducers is derived.

Measuring the magnetic axis alignment during solenoids working.

Several studies reported a high incidence of pulmonary embolism (PE) among patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, but detailed data about clinical characteristics, risk factors of these patients and prognostic role of PE are still lacking. We aim to evaluate the occurrence of pulmonary embolism among patients with SARS-CoV-2 infection, and to describe their risk factors, clinical characteristics, and in-hospital clinical outcomes.

Incidence and characterization of acute pulmonary embolism in patients with SARS-CoV-2 pneumonia: A multicenter Italian experience.

Cardiovascular involvement is a common complication of COVID-19 infection and is associated to increased risk of unfavorable outcome. Advanced imaging modalities (coronary CT angiography and Cardiac Magnetic Resonance) play a crucial role in the diagnosis, follow-up and risk stratification of patients affected by COVID-19 pneumonia with suspected cardiovascular involvement. In the present manuscript we firstly review current knowledge on the mechanisms by which SARS-CoV-2 can trigger endothelial and myocardial damage. Secondly, the implications of the cardiovascular damage on patient's prognosis are presented. Finally, we provide an overview of the main findings at advanced cardiac imaging characterizing COVID-19 in the acute setting, in the post-acute syndrome, and after vaccination, emphasizing the potentiality of CT and CMR, the indication and their clinical implications.

Antonio Esposito

Department of Electrical Engineering and Information Technology (DIETI),
Advanced Metrological Services Center (CeSMA)

University of Naples Federico II

A Single-Channel and Non-Invasive Wearable Brain-Computer Interface for Industry and Healthcare

Antonio Esposito

Department of Electrical Engineering and Information Technology (DIETI),Advanced Metrological Services Center (CeSMA)

University of Naples Federico II

A Single-Channel and Non-Invasive Wearable Brain-Computer Interface for Industry and Healthcare

Department of Electrical Engineering and Information Technology (DIETI),
Advanced Metrological Services Center (CeSMA)