Lei Wu

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met.

Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking.

Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins.

Pillar[5]arene-based diglycolamides for highly efficient separation of americium(III) and europium(III).

Ditopic CMPO-pillar[5]arenes as unique receptors for efficient separation of americium(III) and europium(III).

A non-symmetric pillar[5]arene based on triazole-linked 8-oxyquinolines as a sequential sensor for thorium(IV) followed by fluoride ions.

Human eukaryotic elongation factor 1A forms oligomers through specific cysteine residues.

Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells.

Rheological properties of glutaraldehyde-crosslinked collagen solutions analyzed quantitatively using mechanical models.

Role of reactive oxygen species-mediated MAPK and NF-κB activation in polygonatum cyrtonema lectin-induced apoptosis and autophagy in human lung adenocarcinoma A549 cells.

Enhanced Oral Delivery of Protein Drugs Using Zwitterion-Functionalized Nanoparticles to Overcome both the Diffusion and Absorption Barriers.

Highly efficient extraction of actinides with pillar[5]arene-derived diglycolamides in ionic liquids via a unique mechanism involving competitive host-guest interactions.

A pH-responsive sequential-disassembly nanohybrid for mitochondrial targeting.

Subcellular co-delivery of two different site-oriented payloads for tumor therapy.

Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneously in oral administration.

Systematic evaluation of the toxicity and biodistribution of virus mimicking mucus-penetrating DLPC-NPs as oral drug delivery system.

Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs.

Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties.

The combination of endolysosomal escape and basolateral stimulation to overcome the difficulties of "easy uptake hard transcytosis" of ligand-modified nanoparticles in oral drug delivery.

Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin.

Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota.

Transport Mechanisms of Butyrate Modified Nanoparticles: Insight into "Easy Entry, Hard Transcytosis" of Active Targeting System in Oral Administration.

Novel Self-Assembled Micelles Based on Cholesterol-Modified Antimicrobial Peptide (DP7) for Safe and Effective Systemic Administration in Animal Models of Bacterial Infection.

Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway.

Prevotella copri is associated with carboplatin-induced gut toxicity.

Nanoparticles with surface features of dendritic oligopeptides as potential oral drug delivery systems.

Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery.

A strategy for developing effective orally-delivered nanoparticles through modulation of the surface "hydrophilicity/hydrophobicity balance".

Core-shell stability of nanoparticles plays an important role for overcoming the intestinal mucus and epithelium barrier.

Enhanced nuclear delivery of anti-cancer drugs using micelles containing releasable membrane fusion peptide and nuclear-targeting retinoic acid.

Promoting apical-to-basolateral unidirectional transport of nanoformulations by manipulating the nutrient-absorption pathway.

A novel in silico antimicrobial peptide DP7 combats MDR Pseudomonas aeruginosa and related biofilm infections.

A chromosome-scale reference genome of Lobularia maritima, an ornamental plant with high stress tolerance.

Status of Immunotherapy Acceptance in Chinese Patients With Multiple Sclerosis: Analysis of .

Halogen-Free Flame Retardant Polypropylene Fibers with Modified Intumescent Flame Retardant: Preparation, Characterization, Properties and Mode of Action.

Self-Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy.

Identification of MDM2, YTHDF2 and DDX21 as potential biomarkers and targets for treatment of type 2 diabetes.

A DNA Nanoraft-Based Cytokine Delivery Platform for Alleviation of Acute Kidney Injury.

An extension of the RIGHT statement for introductions and interpretations of clinical practice guidelines: RIGHT for INT.

Structure and properties of halogen-free flame retardant and phosphorus-containing aromatic poly(1,3,4-oxadiazole)s fiber.

Pulsed electromagnetic fields attenuate glucocorticoid-induced bone loss by targeting senescent LepR bone marrow mesenchymal stromal cells.

A Multi-Scale Simulation Study of Irradiation Swelling of Silicon Carbide.

Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for Diabetic Alveolar Bone Rebuilding.

Milk-derived exosomes exhibit versatile effects for improved oral drug delivery.

Treatment outcomes of injectable thermosensitive hydrogel containing bevacizumab in intervertebral disc degeneration.

CT-based transformer model for non-invasively predicting the Fuhrman nuclear grade of clear cell renal cell carcinoma.

Mimicking natural cholesterol assimilation to elevate the oral delivery of liraglutide for type II diabetes therapy.

Efficacy and safety of neoadjuvant immunotherapy in resectable esophageal or gastroesophageal junction carcinoma: A pooled analysis of prospective clinical trials.

Sustained delivery of IL-10 by self-assembling peptide hydrogel to reprogram macrophages and promote diabetic alveolar bone defect healing.

Identification of priority pathogens for aetiological diagnosis in adults with community-acquired pneumonia in China: a multicentre prospective study.

A robust mixed-charge zwitterionic polyurethane coating integrated with antibacterial and anticoagulant functions for interventional blood-contacting devices.

Low-Temperature Assembling Strategy of a Nacre-Inspired Lamellar Configuration to Upcycling Biaxially Oriented Polypropylene Film Waste.

Multifunctional DNA-Based Hydrogel Promotes Diabetic Alveolar Bone Defect Reconstruction.

Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding.

Evolving landscape of treatments targeting the microenvironment of liver metastases in non-small cell lung cancer.