Christopher S. Thom

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.

Hemoglobin variants: biochemical properties and clinical correlates.

Trim58 degrades Dynein and regulates terminal erythropoiesis.

FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology.

Utility and limitations of exome sequencing in the molecular diagnosis of pediatric inherited platelet disorders.

Nonspecific inhibition of erythropoiesis by short hairpin RNAs.

The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia.

Neonatal platelet count trends during inhaled nitric oxide therapy.

Thrombocytosis in an infant with a mutation: a case report.

Tropomyosin 1 genetically constrains in vitro hematopoiesis.

Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes.

Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease.

Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients.

Airway emergency management in a pediatric hospital before and during the COVID-19 pandemic.

Airway emergency management in a pediatric hospital before and during the COVID-19 pandemic.

Mechanistic and Translational Advances Using iPSC-Derived Blood Cells.

High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients.

Body mass index and adipose distribution have opposing genetic impacts on human blood traits.

TSABL: Trait Specific Annotation Based Locus predictor.

Genetically influenced tobacco and alcohol use behaviors impact erythroid trait variation.

Generation of a human knockout iPSC line.

Mendelian randomization analyses clarify the effects of height on cardiovascular diseases.

Generation of a human Tropomyosin 1 knockout iPSC line.

Neonatal Thrombocytopenia as a Presenting Finding in de novo Pyruvate Kinase Deficiency.

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis.

Phosphoproteomics reveals content and signaling differences between neonatal and adult platelets.

Quantitative label-free mass spectrometry reveals content and signaling differences between neonatal and adult platelets.

Modeling primitive and definitive erythropoiesis with induced pluripotent stem cells.