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Robert W. Sobol

Department of Pharmacology & Chemical Biology

University of Pittsburgh School of Medicine

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PUBLICATIONS

Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress.

Proceedings of the National Academy of Sciences of the United States of America May, 2002 | Pubmed ID: 11983862

Binary system for selective photoaffinity labeling of base excision repair DNA polymerases.

Nucleic acids research Jul, 2002 | Pubmed ID: 12136121

Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage.

DNA repair Apr, 2002 | Pubmed ID: 12509250

Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.

DNA repair May, 2003 | Pubmed ID: 12713817

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12882965

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.

Cancer research Sep, 2003 | Pubmed ID: 14522902

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.

The Journal of clinical investigation Jun, 2004 | Pubmed ID: 15199406

Cancer research Jul, 2005 | Pubmed ID: 16024643

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Jul, 2006 | Pubmed ID: 16849758

DNA repair Jan, 2007 | Pubmed ID: 16979388

The American journal of pathology Nov, 2006 | Pubmed ID: 17071602

Cancer research Mar, 2007 | Pubmed ID: 17332367

DNA repair Jun, 2007 | Pubmed ID: 17337257

Molecular cell Feb, 2008 | Pubmed ID: 18313379

Molecular pharmacology Aug, 2008 | Pubmed ID: 18477668

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2008 | Pubmed ID: 18614692

Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice.

Biology of reproduction Nov, 2008 | Pubmed ID: 18650495

Proceedings of the National Academy of Sciences of the United States of America Jun, 2009 | Pubmed ID: 19520829

Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.

PloS one , 2009 | Pubmed ID: 19654874

BMC cancer , 2009 | Pubmed ID: 19807915

Carcinogenesis Dec, 2009 | Pubmed ID: 19864471

DNA polymerase beta-dependent long patch base excision repair in living cells.

DNA repair Feb, 2010 | Pubmed ID: 20006562

Molecular cancer research : MCR Jan, 2010 | Pubmed ID: 20068071

Mutation research Apr, 2010 | Pubmed ID: 20096707

Carcinogenesis May, 2010 | Pubmed ID: 20197299

Pediatric blood & cancer Dec, 2010 | Pubmed ID: 20589656

Antioxidants & redox signaling Jun, 2011 | Pubmed ID: 20649466

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Jan, 2011 | Pubmed ID: 20725730

BMC medical genomics , 2011 | Pubmed ID: 21269491

The Journal of biological chemistry Apr, 2011 | Pubmed ID: 21357694

Neuro-oncology May, 2011 | Pubmed ID: 21377995

Cancer research Mar, 2011 | Pubmed ID: 21406402

Cancer Apr, 2011 | Pubmed ID: 21425146

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

Cancer research May, 2011 | Pubmed ID: 21444671

The base excision repair pathway is required for efficient lentivirus integration.

PloS one , 2011 | Pubmed ID: 21448280

XRCC1 and base excision repair balance in response to nitric oxide.

DNA repair Dec, 2011 | Pubmed ID: 22041025

Current molecular pharmacology Jan, 2012 | Pubmed ID: 22122465

Chemistry & biology Mar, 2012 | Pubmed ID: 22444586

Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors.

Biochemistry Jul, 2012 | Pubmed ID: 22788932

INSTITUTIONS

University of Pittsburgh School of Medicine

University of Pittsburgh Cancer Institute

University of Pittsburgh School of Public Health

JOVE ARTICLES

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons

David Svilar^1,2,

Conchita Vens³,

Robert W. Sobol^1,2,4

¹Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine,

²Hillman Cancer Center, University of Pittsburgh Cancer Institute,

³Department of Experimental Therapy, The Netherlands Cancer Institute,

⁴Department of Human Genetics, University of Pittsburgh School of Public Health

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