Eugene O. Major

HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology.

Analysis of the temporal expression of nestin in human fetal brain derived neuronal and glial progenitor cells.

Traffic of JC virus from sites of initial infection to the brain: the path to progressive multifocal leukoencephalopathy.

Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport.

Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassays.

Advances in the biology of JC virus and induction of progressive multifocal leukoencephalopathy.

Basic, clinical, and epidemiological studies of progressive multifocal leukoencephalopathy: implications for therapy.

Lineage pathway of human brain progenitor cells identified by JC virus susceptibility.

Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors.

Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization.

Analysis of the excreted JC virus strains and their potential oral transmission.

HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro.

JC virus induces nonapoptotic cell death of human central nervous system progenitor cell-derived astrocytes.

Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells.

Comparison of PCR-southern hybridization and quantitative real-time PCR for the detection of JC and BK viral nucleotide sequences in urine and cerebrospinal fluid.

Differential effects of interferon-gamma on the expression of cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes.

Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories.

Nuclear receptor activation and interaction with morphine.

Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathway.

Variant-specific tropism of human herpesvirus 6 in human astrocytes.

Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia.

Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells.

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.

JC virus can infect human immune and nervous system progenitor cells: implications for pathogenesis.

Neural progenitors and HIV-1-associated central nervous system disease in adults and children.

Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.

Viral proteomics: a promising approach for understanding JC virus tropism.

Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells.

Induction of original phenotype of human immortalized chondrocytes: a quantitative gene expression analysis.

MEK1/2 inhibitors block basal and transforming growth factor 1beta1-stimulated JC virus multiplication.

Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring.

Evidence of human immunodeficiency virus type 1 infection of nestin-positive neural progenitors in archival pediatric brain tissue.

NeuroAIDS, drug abuse, and inflammation: building collaborative research activities.

DNA-binding transcription factor NF-1A negatively regulates JC virus multiplication.

BK virus antibody titers and intensity of infections after renal transplantation.

Neuropharmacology of HIV/AIDS.

M- and T-tropic HIVs promote apoptosis in rat neurons.

Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism.

Response to Linberg et al. Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients.

Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project.

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project.

Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies.

Reemergence of PML in natalizumab-treated patients--new cases, same concerns.

Progressive multifocal leukoencephalopathy after natalizumab monotherapy.

Monoclonal antibodies and progressive multifocal leukoencephalopathy.

Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy.

Rearranged JC virus noncoding control regions found in progressive multifocal leukoencephalopathy patient samples increase virus early gene expression and replication rate.

JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab.

Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures.

Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity.

CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes.

Inhibitory interactions between BK and JC virus among kidney transplant recipients.

IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner.

Taxonomical developments in the family Polyomaviridae.

Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring.

JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytes.

History and current concepts in the pathogenesis of PML.

The link between VLA-4 and JC virus reactivation.

Individuals infected with JC polyomavirus do not present detectable JC virus DNA in oropharyngeal fluids.

Neurological infections: risks of globalisation and new drugs.

Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.

Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy.

Human Immunodeficiency Virus Type 1 (HIV-1) Transactivator of Transcription through Its Intact Core and Cysteine-Rich Domains Inhibits Wnt/β-Catenin Signaling in Astrocytes: Relevance to HIV Neuropathogenesis.