Wah Chiu

Quaternary structure of human fatty acid synthase by electron cryomicroscopy.

Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses.

High resolution structural studies of complex icosahedral viruses: a brief overview.

Electron cryo-microscopy of VAT, the archaeal p97/CDC48 homologue from Thermoplasma acidophilum.

Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches.

The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain.

Structure of isolated nucleocapsids from venezuelan equine encephalitis virus and implications for assembly and disassembly of enveloped virus.

Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions.

Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP.

Structure of the herpesvirus major capsid protein.

Web-based Simulation for Contrast Transfer Function and Envelope Functions.

Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy.

Multislice computed tomography angiography in pediatric liver transplantation.

Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics.

Virus structure. Preface.

Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution.

Studying large viruses.

The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state.

Focal pair merging for contrast enhancement of single particles.

Applications of a bilateral denoising filter in biological electron microscopy.

Structure of triglyceride-rich human low-density lipoproteins according to cryoelectron microscopy.

Object oriented database and electronic notebook for transmission electron microscopy.

Electron beam coater for reduction of charging in ice-embedded biological specimens using Ti(88)Si(12) alloy.

Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis.

Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP.

A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope.

Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion.

SARS in newborns and children.

Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy.

Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.

Structure of the acrosomal bundle.

Structure of Ca2+ release channel at 14 A resolution.

Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy.

Electron cryomicroscopy of biological machines at subnanometer resolution.

The pore structure of the closed RyR1 channel.

A digital atlas to characterize the mouse brain transcriptome.

Fast rotational matching of single-particle images.

Common ancestry of herpesviruses and tailed DNA bacteriophages.

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation.

Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus.

Structural biology of cellular machines.

Refinement of protein structures by iterative comparative modeling and CryoEM density fitting.

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids.

3D volume reconstruction of a mouse brain from histological sections using warp filtering.

Hybrid segmentation framework for tissue images containing gene expression data.

Cryo-EM asymmetric reconstruction of bacteriophage P22 reveals organization of its DNA packaging and infecting machinery.

Automated segmentation of molecular subunits in electron cryomicroscopy density maps.

Outcome of a workshop on archiving structural models of biological macromolecules.

Cryoelectron microscopy of protein IX-modified adenoviruses suggests a new position for the C terminus of protein IX.

Structure of Halothiobacillus neapolitanus carboxysomes by cryo-electron tomography.

Assessing the capabilities of a 4kx4k CCD camera for electron cryo-microscopy at 300kV.

Ab initio modeling of the herpesvirus VP26 core domain assessed by CryoEM density.

An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate.

Electron cryotomography reveals the portal in the herpesvirus capsid.

Identification of secondary structure elements in intermediate-resolution density maps.

Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction.

Genome sequence, structural proteins, and capsid organization of the cyanophage Syn5: a "horned" bacteriophage of marine synechococcus.

DNA packaging and delivery machines in tailed bacteriophages.

Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins.

Learning-based segmentation framework for tissue images containing gene expression data.

Cryoelectron microscopy of icosahedral virus particles.

Averaging tens to hundreds of icosahedral particle images to resolve protein secondary structure elements using a Multi-Path Simulated Annealing optimization algorithm.

Biophysical methods: structure, dynamics and gorgeous images.

Crystallographic conformers of actin in a biologically active bundle of filaments.

Modular software platform for low-dose electron microscopy and tomography.

Protein structure fitting and refinement guided by cryo-EM density.

Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy.

De novo backbone trace of GroEL from single particle electron cryomicroscopy.

Computing a family of skeletons of volumetric models for shape description.

Achievable resolution from images of biological specimens acquired from a 4k x 4k CCD camera in a 300-kV electron cryomicroscope.

Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT.

Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells.

Location and flexibility of the unique C-terminal tail of Aquifex aeolicus co-chaperonin protein 10 as derived by cryo-electron microscopy and biophysical techniques.

Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel.

JADAS: a customizable automated data acquisition system and its application to ice-embedded single particles.

Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM.

Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy.

Refinement of protein structures into low-resolution density maps using rosetta.

Automated pipeline for atlas-based annotation of gene expression patterns: application to postnatal day 7 mouse brain.

Radiation damage effects at four specimen temperatures from 4 to 100 K.

Model of human low-density lipoprotein and bound receptor based on cryoEM.

Mechanism of folding chamber closure in a group II chaperonin.

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement.

Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions.

Automated specimen search in cryo-TEM observation with DIFF-defocus imaging.

Tracing conformational changes in proteins.

MOTIF-EM: an automated computational tool for identifying conserved regions in CryoEM structures.

Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus.

Identifying Components in 3D Density Maps of Protein Nanomachines by Multi-scale Segmentation.

A geometric database for gene expression data.

Zernike phase contrast cryo-electron microscopy and tomography for structure determination at nanometer and subnanometer resolutions.

Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection.

Cryo-EM of macromolecular assemblies at near-atomic resolution.

Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography.

EMDataBank.org: unified data resource for CryoEM.

Workshop on molecular animation.

The group II chaperonin Mm-Cpn binds and refolds human γD crystallin.

Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy.

Workshop on the validation and modeling of electron cryo-microscopy structures of biological nanomachines.

Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus.

Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber.

Modeling protein structure at near atomic resolutions with Gorgon.

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses.

Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug delivery.

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure.

Practical performance evaluation of a 10k × 10k CCD for electron cryo-microscopy.

Structure of Trypanosoma brucei flagellum accounts for its bihelical motion.

The structure of barmah forest virus as revealed by cryo-electron microscopy at a 6-angstrom resolution has detailed transmembrane protein architecture and interactions.

Flexible architecture of IP3R1 by Cryo-EM.

4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus.

Near-atomic-resolution cryo-EM for molecular virology.

A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB.

Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle.

Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model.

Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency.

Reconstructing virus structures from nanometer to near-atomic resolutions with cryo-electron microscopy and tomography.

Outcome of the first electron microscopy validation task force meeting.

Paraneoplastic thrombocytosis in ovarian cancer.

Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation.

Constructing and validating initial Cα models from subnanometer resolution density maps with pathwalking.

An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs.

The molecular architecture of the eukaryotic chaperonin TRiC/CCT.

The 2010 cryo-EM modeling challenge.

Gorgon and pathwalking: macromolecular modeling tools for subnanometer resolution density maps.

Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps.

A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions.

Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration.

EMEN2: an object oriented database and electronic lab notebook.

Cryo-EM structure of a molluscan hemocyanin suggests its allosteric mechanism.

Cryo-EM model validation using independent map reconstructions.

Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.

Validation of cryo-EM structure of IP₃R1 channel.

Visualizing GroEL/ES in the act of encapsulating a folding protein.

Validated near-atomic resolution structure of bacteriophage epsilon15 derived from cryo-EM and modeling.

TRiC's tricks inhibit huntingtin aggregation.

Exploring new limits in complex biological structures.

Visualizing virus assembly intermediates inside marine cyanobacteria.

Reprogramming an ATP-driven protein machine into a light-gated nanocage.