Marco Vignuzzi

Expression of a membrane-anchored glycoprotein, the influenza virus hemagglutinin, by dicistronic replicons derived from the poliovirus genome.

Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications.

Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase.

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population.

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.

Engineering attenuated virus vaccines by controlling replication fidelity.

Delivery of mengovirus-derived RNA replicons into tumoural liver enhances the anti-tumour efficacy of a peripheral peptide-based vaccine.

Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines.

Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures.

Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.

Arbovirus high fidelity variant loses fitness in mosquitoes and mice.

Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.