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Klinikum Chemnitz GmbH

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Engineering

Normothermic Ex Vivo Liver Machine Perfusion in Mouse
Haotian Chen 1, Olaf Dirsch 2, Mohamed Albadry 1,3, Paz Hernandez Ana 1, Uta Dahmen 1
1Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 2Institute of Pathology, Klinikum Chemnitz GmbH, 3Department of Pathology, Faculty of Veterinary Medicine, Menoufia University

A normothermic ex vivo liver perfusion (NEVLP) system was created for mouse livers. This system requires experience in microsurgery but allows for reproducible perfusion results. The ability to utilize mouse livers facilitates the investigation of molecular pathways to identify novel perfusate additives and enables the execution of experiments focused on organ repair.

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