Accedi

Gwangju Institute of Science and Technology

4 ARTICLES PUBLISHED IN JoVE

Neuroscience

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Sung Wook Park^1,2, Jin Hyoung Kim², Woo Jin Park³, Jeong Hun Kim^1,2,4

¹Department of Biomedical Sciences, Seoul National University College of Medicine, ²FARB Laboratory, Biomedical Research Institute, Seoul National University Hospital, ³College of Life Sciences, Gwangju Institute of Science and Technology, ⁴Department of Ophthalmology, Seoul National University College of Medicine

Subretinal injection is a surgical technique for effective gene delivery to retinal pigment epithelium in the mouse eye. Here we describe an easy and replicable method for subretinal injection of viral vectors to retinal pigment epithelium in experimental mice.

Medicine

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Hanlim Song¹, Ji-Young Park¹, Hyung-Sun Kim¹, Min-Cheol Lee², Young Kim², Hyoung-Ihl Kim^1,3

¹Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, ²Department of Pathology, Chonnam National University Medical School, ³Departement of Neurosurgery, Presbyterian Medical Center

This manuscript describes a modeling technique of capsular infarct. Here we utilized a modified photothrombotic technique with low intensity of light after pre-surgery target mapping. Using this technique, we created a circumscribed capsular infarct model with persistent motor impairment.

Engineering

Fabrication of Ultra-thin Color Films with Highly Absorbing Media Using Oblique Angle Deposition

Young Jin Yoo¹, Gil Ju Lee¹, Kyung-In Jang², Young Min Song¹

¹School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, ²Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology

We present a detailed method for fabricating ultra-thin color films with improved characteristics for optical coatings. The oblique angle deposition technique using an electron beam evaporator allows improved color tunability and purity. Fabricated films of Ge and Au on Si substrates were analyzed by reflectance measurements and color information conversion.

Engineering

Fabrication of Flexible Image Sensor Based on Lateral NIPIN Phototransistors

Hyun Myung Kim^*1, Gil Ju Lee^*1, Min Seok Kim¹, Young Min Song¹

¹School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology

We present a detailed method to fabricate a deformable lateral NIPIN phototransistor array for curved image sensors. The phototransistor array with an open mesh form, which is composed of thin silicon islands and stretchable metal interconnectors, provides flexibility and stretchability. The parameter analyzer characterizes the electrical property of the fabricated phototransistor.