Accedi

Uniformed Services University of the Health Sciences, Bethesda, Maryland

2 ARTICLES PUBLISHED IN JoVE

Medicine

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Min Jia¹, Fei Meng², Stanley E. Smerin¹, Guoqiang Xing¹, Lei Zhang¹, David M. Su², David Benedek¹, Robert Ursano¹, Yan A. Su², He Li¹

¹Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, Maryland, ²Department of Gene and Protein Biomarkers, GenProMarkers, Inc.

We describe a rat model of post traumatic stress disorder (PTSD) that reveals the persistent alterations in neuroendocrine function and the delayed long-term, exaggerated fear response, characteristic of PTSD patients. The animal model and methods described here are useful for correlating biomarkers in brain nuclei, which are mechanistic but cannot be measured in patients, with biomarkers in peripheral white blood cells, which can.

Medicine

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Chenhao Hu^*1,2,3, Zhe Zhang^*1,2,3, Lei Zhang^1,2,3, Ruihan Liu^2,3, Jun Yan^1,2,3, Qi Sun^1,2,3, Guanghui Wang¹, Junjun She^1,2,3

¹Department of General Surgery, The First Affiliated Hospital of Xian Jiaotong University, ²Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xian Jiao tong University, ³Department of High Talent, The First Affiliated Hospital of Xian Jiaotong University

The robotic technique described herein aims to detail a stepwise approach to robot-assisted total mesorectal excision and lateral pelvic lymph node dissection for locally advanced (T3/T4) rectal cancer located below the peritoneal reflection.