Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 MiceMariana B. Serra *1, Márcia K. Koike *1, Denise F. Barbeiro *1, Marcel C. C. Machado *1, Heraldo P. de Souza *1
1Discipline of Clinical Emergencies, Department of Clinical Medicine, HCFMUSP / LIM 51, University of São Paulo Medical School
Animal models for severe acute pancreatitis enable the study of pathophysiological changes at the initial stage, facilitating observation of the evolution of inflammatory events. Here we provide a protocol for the induction of severe acute biliary pancreatitis by retrograde infusion of sodium taurocholate into the pancreatic duct of anesthetized C57BL/6 mice.
