Acclimate Animals for 4 Weeks and Induce MetS for 28 Weeks
2:30
Morphological Assessment
3:48
Fasting Glycemia and Intravenous Glucose Tolerance Test
5:14
Blood Pressure
6:55
Plasma Measurements
7:57
Results: Assessment of Diet-induced Metabolic Syndrome in Rabbits
9:48
Conclusion
Trascrizione
The overall goal of this procedure is to develop and characterize a metabolic syndrome model in rabbits using a high fat, high sucrose diet, which is of great importance when associating a phenotype with organ remodeling. This method can help answ
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We describe methods to develop an experimental model of diet-induced metabolic syndrome (MetS) in rabbits using a high-fat, high-sucrose diet. Animals developed central obesity, mild hypertension, pre-diabetes, and dyslipidemia, thus reproducing the main components of human MetS. This chronic model will allow acquisition of knowledge underlying mechanisms of disease progression.