This method can help answer key questions in fracture healing research about the biological mechanisms of repair and the development of novel therapeutic strategies for promoting efficient bone healing. The main advantage of this technique is that
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The murine closed femoral fracture model is a powerful platform to study fracture healing and novel therapeutic strategies to accelerate bone regeneration. The goal of this surgical protocol is to generate unilateral closed femoral fractures in mice using an intramedullary steel rod to stabilize the femur.