Carole L. Yauk

A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus.

Air pollution induces heritable DNA mutations.

Advances in the application of germline tandem repeat instability for in situ monitoring.

Comprehensive comparison of six microarray technologies.

A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.

Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid.

Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.

Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray.

Review of the literature examining the correlation among DNA microarray technologies.

Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element.

Mainstream tobacco smoke causes paternal germ-line DNA mutation.

Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field.

Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action.

Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart.

Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-chip in developing mouse cerebellum.

Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation.

Impact of nose-only exposure system on pulmonary gene expression.

Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke.

Cross-platform analysis of global microRNA expression technologies.

Acetaminophen modulates the transcriptional response to recombinant interferon-beta.

Germ cell mutagens: risk assessment challenges in the 21st century.

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study.

Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice.

Germline mutation rates in mice following in utero exposure to diesel exhaust particles by maternal inhalation.

Sidestream tobacco smoke is a male germ cell mutagen.

Hepatic mRNA, microRNA, and miR-34a-target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation.

Technical-grade perfluorooctane sulfonate alters the expression of more transcripts in cultured chicken embryonic hepatocytes than linear perfluorooctane sulfonate.

Exposure of pregnant mice to carbon black by intratracheal instillation: Toxicogenomic effects in dams and offspring.

Barhl1 is directly regulated by thyroid hormone in the developing cerebellum of mice.

Thyroid hormone-regulated gene expression in juvenile mouse liver: identification of thyroid response elements using microarray profiling and in silico analyses.

Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver.

Overexpression of tumor necrosis factor-α in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways.

Genetic toxicology and toxicogenomic analysis of three cigarette smoke condensates in vitro reveals few differences among full-flavor, blonde, and light products.

Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice.

Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis.

NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice.

Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung.

Transcriptional profiles in the cerebral hemisphere of chicken embryos following in ovo perfluorohexane sulfonate exposure.

Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice.

Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure.

The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development.

IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation.

Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society.

Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform.

No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.

Mice exposed in situ to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet synthesis pathways.

A global toxicogenomic analysis investigating the mechanistic differences between tobacco and marijuana smoke condensates in vitro.

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation.

In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA.

Identification of thyroid hormone receptor binding sites in developing mouse cerebellum.

Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: relevance to human cancer risk.

Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene.

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan.

In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells.

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

Carbon black nanoparticle intratracheal instillation does not alter cardiac gene expression.

Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.

Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells.

Tris(1,3-dichloro-2-propyl) phosphate perturbs the expression of genes involved in immune response and lipid and steroid metabolism in chicken embryos.

Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study.

Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver.

Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease.

Thyroid hormone response element half-site organization and its effect on thyroid hormone mediated transcription.

Identification of mechanisms of action of bisphenol A-induced human preadipocyte differentiation by transcriptional profiling.